Show simple item record

dc.contributor.authorPrevete, Elisabeth
dc.contributor.authorKuypers, Kim Paula Colette
dc.contributor.authorTheunissen, Eef Lien
dc.contributor.authorCorazza, Ornella
dc.contributor.authorBersani, Giuseppe
dc.contributor.authorRamaekers, Johannes Gerardus
dc.date.accessioned2021-08-02T10:15:01Z
dc.date.available2021-08-02T10:15:01Z
dc.date.issued2021-07-26
dc.identifier.citationPrevete , E , Kuypers , K P C , Theunissen , E L , Corazza , O , Bersani , G & Ramaekers , J G 2021 , ' A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans ' , Human Psychopharmacology . https://doi.org/10.1002/hup.2805
dc.identifier.issn0885-6222
dc.identifier.otherPURE: 25707635
dc.identifier.otherPURE UUID: 8239d6d8-0422-45c6-a5c7-a41a5aaf4983
dc.identifier.otherPubMed: 34309900
dc.identifier.otherScopus: 85111170173
dc.identifier.urihttp://hdl.handle.net/2299/24938
dc.description© 2021 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, https://creativecommons.org/licenses/by-nc/4.0/.
dc.description.abstractINTRODUCTION: Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an ethnomedicinal remedy for several conditions in South East Asia. Despite the increased interest in its therapeutical benefits in Western countries, little scientific evidence is available to support such claims, and existing data remain limited to kratom's chronic consumption. OBJECTIVE: Our study aims to investigate (pre)clinical evidence on the efficacy of kratom as a therapeutic aid and its safety profile in humans. METHODS: A systematic literature search using PubMed and the Medline database was conducted between April and November 2020. RESULTS: Both preclinical (N = 57) and clinical (N = 18) studies emerged from our search. Preclinical data indicated a therapeutic value in terms of acute/chronic pain (N = 23), morphine/ethanol withdrawal, and dependence (N = 14), among other medical conditions (N = 26). Clinical data included interventional studies (N = 2) reporting reduced pain sensitivity, and observational studies (N = 9) describing the association between kratom's chronic (daily/frequent) use and safety issues, in terms of health consequences (e.g., learning impairment, high cholesterol level, dependence/withdrawal).CONCLUSIONS: Although the initial (pre)clinical evidence on kratom's therapeutic potential and its safety profile in humans is encouraging, further validation in large, controlled clinical trials is required.en
dc.format.extent33
dc.language.isoeng
dc.relation.ispartofHuman Psychopharmacology
dc.titleA systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humansen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionUniversity of Hertfordshire
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1002/hup.2805
rioxxterms.typeOther
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record