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dc.contributor.authorSalomone, Alberto
dc.contributor.authorLevari, Ermelinda
dc.contributor.authorLotti, Andrea
dc.contributor.authorFrenguelli, Marinella
dc.contributor.authorLongo, Valentina
dc.contributor.authorGottardi, Massimo
dc.contributor.authorMarchio, Giovanni Michele
dc.contributor.authorStefani, Martina
dc.contributor.authorFerrucci, Roberta
dc.contributor.authorNegri, Attilio
dc.contributor.authorCorazza, Ornella
dc.date.accessioned2021-08-19T11:45:02Z
dc.date.available2021-08-19T11:45:02Z
dc.date.issued2021-08-10
dc.identifier.citationSalomone , A , Levari , E , Lotti , A , Frenguelli , M , Longo , V , Gottardi , M , Marchio , G M , Stefani , M , Ferrucci , R , Negri , A & Corazza , O 2021 , ' Preliminary assessment of fentanyl and synthetic opioids prevalence among addiction patients by means of hair analysis ' , Emerging Trends in Drugs, Addictions and Health , vol. 2021 , no. 1 , 100020 . https://doi.org/10.1016/j.etdah.2021.100020
dc.identifier.issn2667-1182
dc.identifier.otherPURE: 25791553
dc.identifier.otherPURE UUID: f7c7479b-c236-43c9-b2ec-b0570dcbffaa
dc.identifier.otherJisc: 70990f5551384660925b1dad9fe925bc
dc.identifier.otherORCID: /0000-0001-7371-319X/work/98752672
dc.identifier.urihttp://hdl.handle.net/2299/24987
dc.description.abstractBackground Although the diffusion of novel synthetic opioids has become a worldwide phenomenon, their prevalence of use in Italy seems to be limited. Existing national data is mainly derived by anamnestic surveyslacking of toxicological validation and not always disclosing the use of these compounds, which might remain under-diagnosed. Methods an assessment of the metabolites of the main synthetic opioids on hair samples was carried out among patients admitted at the Addiction Treatment Unit of Trento. The analytical approach included: (a) screening by means of immunoenzymatic method for fentanyl, fentanyl analogs and oxicodone; (b) confirmation of the samples resulted positive for fentanyl and oxicodone by means of HPLC-MS/; (c) search and dosage detection of Tramadol by means of HPLC-MS/MS. Results 3 out of 309 analysed samples were found positive: one was positive to Fentanyl and two to 4-ANPP. In the same cohort, 6 samples were also found positive for Oxycodone . Tramadol was searched in 189 samples and 12 of them resulted positive. Discussion and conclusion Those found positive were mainly young adults engaging in dangerous patterns of use and lacking awareness of risks. The phenomenon requires further consideration by health professionals. Training and more evidence-based information on synthetic opioids as well as other Novel Psychoactive Substances (NPS) are urgently needed.en
dc.language.isoeng
dc.relation.ispartofEmerging Trends in Drugs, Addictions and Health
dc.titlePreliminary assessment of fentanyl and synthetic opioids prevalence among addiction patients by means of hair analysisen
dc.contributor.institutionToxicology
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.etdah.2021.100020
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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