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dc.contributor.authorGraham, Simon P.
dc.contributor.authorCheong, Yuen-Ki
dc.contributor.authorFurniss, Summer
dc.contributor.authorNixon, Emma
dc.contributor.authorSmith, Joseph A.
dc.contributor.authorYang, Xiuyi
dc.contributor.authorFruengel, Rieke
dc.contributor.authorHussain, Sabha
dc.contributor.authorTchorzewska, Monika A.
dc.contributor.authorLa Ragione, Roberto M.
dc.contributor.authorRen, Guogang
dc.date.accessioned2021-08-23T14:15:07Z
dc.date.available2021-08-23T14:15:07Z
dc.date.issued2021-08-20
dc.identifier.citationGraham , S P , Cheong , Y-K , Furniss , S , Nixon , E , Smith , J A , Yang , X , Fruengel , R , Hussain , S , Tchorzewska , M A , La Ragione , R M & Ren , G 2021 , ' Antiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virus ' , Nanomaterials (Basel, Switzerland) , vol. 11 , no. 8 , 2120 . https://doi.org/10.3390/nano11082120
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 25788106
dc.identifier.otherPURE UUID: e86fb600-d88b-4e9e-819b-671fda7a9fff
dc.identifier.otherJisc: 31146cca17ce4b5cb02cc92a3d3ae9ce
dc.identifier.otherJisc: 31146cca17ce4b5cb02cc92a3d3ae9ce
dc.identifier.otherORCID: /0000-0001-8865-1526/work/99078953
dc.identifier.otherPubMed: 34443950
dc.identifier.otherScopus: 85113534654
dc.identifier.urihttp://hdl.handle.net/2299/24997
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractPorcine reproductive and respiratory syndrome viruses (PRRSV) are responsible for one of the most economically important diseases affecting the global pig industry. On-farm high-efficiency particulate air (HEPA) filtration systems can effectively reduce airborne transmission of PRRSV and the incidence of PRRS, but they are costly, and their adoption is limited. Therefore, there is a need for low-cost alternatives, such as antimicrobial filters impregnated with antiviral nanoparticles (AVNP). During the past 10 years, tailored intermetallic/multi-elemental AVNP compositions have demonstrated effective performance against human viruses. In this study, a panel of five AVNP was evaluated for viricidal activity against PRRSV. Three AVNP materials: AVNP2, copper nanoparticles (CuNP), and copper oxide nanoparticles (CuONP), were shown to exert a significant reduction (>99.99%) in virus titers at 1.0% (w/v) concentration. Among the three, CuNP was the most effective at lower concentrations. Further experiments revealed that AVNP generated significant reductions in viral titers within just 1.5 min. For an optimal reduction in viral titers, direct contact between viruses and AVNP was required. This was further explained by the inert nature of these AVNP, where only negligible leaching concentrations of Ag/Cu ions (0.06–4.06 ppm) were detected in AVNP supernatants. Real-time dynamic light scatting (DLS) and transmission electron microscopic (TEM) analyses suggested that the mono-dispersive hydrodynamic behavior of AVNPs may have enhanced their antiviral activity against PRRSV. Collectively, these data support the further evaluation of these AVNP as candidate nanoparticles for incorporation into antimicrobial air-filtration systems to reduce transmission of PRRSV and other airborne pathogens.en
dc.format.extent14
dc.language.isoeng
dc.relation.ispartofNanomaterials (Basel, Switzerland)
dc.subjectporcine reproductive and respiratory syndrome virus
dc.subjectantiviral nanoparticle
dc.subjectviricidal efficacy
dc.subjectStaphylococcus aureus
dc.subjectPorcine reproductive and respiratory syndrome virus
dc.subjectViricidal efficacy
dc.subjectAntiviral nanoparticle
dc.subjectChemical Engineering(all)
dc.subjectMaterials Science(all)
dc.titleAntiviral Efficacy of Metal and Metal Oxide Nanoparticles against the Porcine Reproductive and Respiratory Syndrome Virusen
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionBioEngineering
dc.contributor.institutionCentre for Engineering Research
dc.contributor.institutionMaterials and Structures
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85113534654&partnerID=8YFLogxK
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/nano11082120
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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