dc.contributor.author | Sheelan, Ahmad, | |
dc.contributor.author | Baker, Daniel | |
dc.contributor.author | Murnane, Darragh | |
dc.contributor.author | Neil, Spooner, | |
dc.contributor.author | Gerhard, Ute | |
dc.date.accessioned | 2021-08-23T14:30:03Z | |
dc.date.available | 2021-08-23T14:30:03Z | |
dc.date.issued | 2021-07-19 | |
dc.identifier.citation | Sheelan , A , Baker , D , Murnane , D , Neil , S & Gerhard , U 2021 , ' Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis ' , Bioanalysis , vol. 13 , no. 14 , pp. 1101-1111 . https://doi.org/10.4155/bio-2021-0109 | |
dc.identifier.issn | 1757-6180 | |
dc.identifier.other | Jisc: b39acad4175d4207b7a597cf5920d6a3 | |
dc.identifier.other | Jisc: b39acad4175d4207b7a597cf5920d6a3 | |
dc.identifier.uri | http://hdl.handle.net/2299/24999 | |
dc.description | © 2021 Future Science Group. | |
dc.description.abstract | Aim: Determination of plasma protein binding (PPB) is considered vital for better understanding of pharmacokinetic and pharmacodynamic activities of drugs due to the role of free concentration in pharmacological response. Methodology & results: Solid-phase microextraction (SPME) was investigated for measurement of PPB from biological matrices and compared with a gold standard approach (rapid equilibrium dialysis [RED]). Discussion & conclusion: SPME-derived values of PPB correlated well with literature values, and those determined by RED. Respectively, average protein binding across three concentrations by RED and SPME was 33.1 and 31.7% for metoprolol, 89.0 and 86.6% for propranolol and 99.2 and 99.0% for diclofenac. This study generates some evidence for SPME as an alternative platform for the determination of PPB. | en |
dc.format.extent | 11 | |
dc.format.extent | 412987 | |
dc.language.iso | eng | |
dc.relation.ispartof | Bioanalysis | |
dc.subject | Preliminary Communication | |
dc.subject | free concentration | |
dc.subject | microsampling | |
dc.subject | plasma protein binding | |
dc.subject | rapid equilibrium dialysis | |
dc.subject | solid-phase microextraction | |
dc.subject | Analytical Chemistry | |
dc.subject | Medical Laboratory Technology | |
dc.subject | Pharmacology, Toxicology and Pharmaceutics(all) | |
dc.subject | Clinical Biochemistry | |
dc.title | Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis | en |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Airway Group | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2022-07-19 | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85111147987&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.4155/bio-2021-0109 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |