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dc.contributor.authorSingh, Kumar Saurabh
dc.contributor.authorCordeiro, Erick M. G.
dc.contributor.authorTroczka, Bartlomiej J.
dc.contributor.authorPym, Adam
dc.contributor.authorMackisack, Joanna
dc.contributor.authorMathers, Thomas C.
dc.contributor.authorDuarte, Ana
dc.contributor.authorLegeai, Fabrice
dc.contributor.authorRobin, Stéphanie
dc.contributor.authorBielza, Pablo
dc.contributor.authorBurrack, Hannah J.
dc.contributor.authorCharaabi, Kamel
dc.contributor.authorDenholm, Ian
dc.contributor.authorFigueroa, Christian C.
dc.contributor.authorffrench-Constant, Richard H.
dc.contributor.authorJander, Georg
dc.contributor.authorMargaritopoulos, John T.
dc.contributor.authorMazzoni, Emanuele
dc.contributor.authorNauen, Ralf
dc.contributor.authorRamírez, Claudio C.
dc.contributor.authorRen, Guangwei
dc.contributor.authorStepanyan, Ilona
dc.contributor.authorUmina, Paul A.
dc.contributor.authorVoronova, Nina V.
dc.contributor.authorVontas, John
dc.contributor.authorWilliamson, Martin S.
dc.contributor.authorWilson, Alex C. C.
dc.contributor.authorXi-Wu, Gao
dc.contributor.authorYoun, Young-Nam
dc.contributor.authorZimmer, Christoph T.
dc.contributor.authorSimon, Jean-Christophe
dc.contributor.authorHayward, Alex
dc.contributor.authorBass, Chris
dc.date.accessioned2021-08-24T14:00:01Z
dc.date.available2021-08-24T14:00:01Z
dc.date.issued2021-07-07
dc.identifier.citationSingh , K S , Cordeiro , E M G , Troczka , B J , Pym , A , Mackisack , J , Mathers , T C , Duarte , A , Legeai , F , Robin , S , Bielza , P , Burrack , H J , Charaabi , K , Denholm , I , Figueroa , C C , ffrench-Constant , R H , Jander , G , Margaritopoulos , J T , Mazzoni , E , Nauen , R , Ramírez , C C , Ren , G , Stepanyan , I , Umina , P A , Voronova , N V , Vontas , J , Williamson , M S , Wilson , A C C , Xi-Wu , G , Youn , Y-N , Zimmer , C T , Simon , J-C , Hayward , A & Bass , C 2021 , ' Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae ' , Communications Biology , vol. 4 , no. 1 , 847 . https://doi.org/10.1038/s42003-021-02373-x
dc.identifier.issn2399-3642
dc.identifier.otherPURE: 25818461
dc.identifier.otherPURE UUID: dd2feaa3-0ed3-479e-9b1a-a10e033ae0bd
dc.identifier.otherJisc: 72060e476709444e9942650f1b2bccfe
dc.identifier.otherpublisher-id: s42003-021-02373-x
dc.identifier.othermanuscript: 2373
dc.identifier.otherScopus: 85109394758
dc.identifier.otherORCID: /0000-0001-9797-874X/work/99079122
dc.identifier.urihttp://hdl.handle.net/2299/25014
dc.description.abstractAbstract: The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.en
dc.language.isoeng
dc.relation.ispartofCommunications Biology
dc.rightsOpen
dc.subjectArticle
dc.subject/631/181/2474
dc.subject/631/208/8
dc.subject/45
dc.subject/45/23
dc.subject/45/43
dc.subjectarticle
dc.titleGlobal patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicaeen
dc.contributor.institutionCentre for Agriculture, Food and Environmental Management Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCrop Protection and Climate Change
dc.contributor.institutionAgriculture, Food and Veterinary Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2021-07-07
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1038/s42003-021-02373-x
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


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