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dc.contributor.authorLambrou, George I.
dc.contributor.authorZaravinos, Apostolos
dc.contributor.authorBraoudaki, Maria
dc.date.accessioned2021-09-01T11:30:02Z
dc.date.available2021-09-01T11:30:02Z
dc.date.issued2021-06-17
dc.identifier.citationLambrou , G I , Zaravinos , A & Braoudaki , M 2021 , ' Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics ' , Cancers , vol. 13 , no. 12 , e3028 . https://doi.org/10.3390/cancers13123028
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 25861418
dc.identifier.otherPURE UUID: 9fe57e32-692d-47b0-b868-397b6142c90b
dc.identifier.otherJisc: 1320f97296454f51be15e00766981110
dc.identifier.otherScopus: 85107939040
dc.identifier.urihttp://hdl.handle.net/2299/25025
dc.description.abstractDespite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. MicroRNAs are known to be involved in CNS tumor oncogenesis. We hypothesized that CNS tumors possess commonly deregulated miRNAs across different CNS tumor types. Aim: The current study aims to reveal the co-deregulated miRNAs across different types of pediatric CNS tumors. Materials: A total of 439 CNS tumor samples were collected from both in-house microarray experiments as well as data available in public databases. Diagnoses included medulloblastoma, astrocytoma, ependydoma, cortical dysplasia, glioblastoma, ATRT, germinoma, teratoma, yoc sac tumors, ocular tumors and retinoblastoma. Results: We found miRNAs that were globally up- or down-regulated in the majority of the CNS tumor samples. MiR-376B and miR-372 were co-upregulated, whereas miR-149, miR-214, miR-574, miR-595 and miR-765 among others, were co-downregulated across all CNS tumors. Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. Conclusions: Our approach could prove significant in the search for global miRNA targets for tumor diagnosis and therapy. To the best of our knowledge, there are no previous reports concerning the present approach.en
dc.language.isoeng
dc.relation.ispartofCancers
dc.subjectcentral nervous system
dc.subjectCNS tumors
dc.subjectpediatric CNS tumors
dc.subjectchildhood CNS tumors
dc.subjectmiRNA
dc.subjectcommon mechanics
dc.subjectmicroarrays
dc.titleCo-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanicsen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.3390/cancers13123028
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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