dc.contributor.author | Rossiter, Sharon | |
dc.contributor.author | Ostovar, Mehrnoosh | |
dc.date.accessioned | 2021-12-06T10:45:02Z | |
dc.date.available | 2021-12-06T10:45:02Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Rossiter , S & Ostovar , M 2022 , Bicyclic 6-6 Systems: Pteridines . in Comprehensive Heterocyclic Chemistry IV . vol. 10 , Elsevier , pp. 796-855 . https://doi.org/10.1016/B978-0-12-818655-8.00040-8 | |
dc.identifier.isbn | 9780128186565 | |
dc.identifier.other | ORCID: /0000-0003-3822-0028/work/142860154 | |
dc.identifier.uri | http://hdl.handle.net/2299/25220 | |
dc.description | © 2022 Elsevier Ltd. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/B978-0-12-818655-8.00040-8 | |
dc.description.abstract | This article describes the literature on pteridines, covering the period from 2008 to 2020. The physical properties and reactions include photochemistry, substitution at ring nitrogens, nucleophilic substitution at ring carbons, organometallic couplings and methods for side chain elaboration and extension. Synthesis of pteridines is mainly from the pyrimidine, but there are examples from the pyrazine. Pteridine biological pigments and enzyme cofactors are widespread, and aspects of biosynthetic pathways are reviewed. Compounds of special interest and applications include metal complexes, nucleic acid analogues, natural products and increasingly the use of the pteridine scaffold in medicinal chemistry. | en |
dc.format.extent | 4066550 | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Comprehensive Heterocyclic Chemistry IV | |
dc.title | Bicyclic 6-6 Systems: Pteridines | en |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
dc.contributor.institution | Natural Product Chemistry and Drug Design | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.date.embargoedUntil | 2022-11-23 | |
rioxxterms.versionofrecord | 10.1016/B978-0-12-818655-8.00040-8 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |