Show simple item record

dc.contributor.authorHaddow, Peter J.
dc.contributor.authorda Silva, Marcelo A.
dc.contributor.authorKaldybekov, Daulet B.
dc.contributor.authorDreiss, Cecile A.
dc.contributor.authorHoffman, Ewelina
dc.contributor.authorHutter, Victoria
dc.contributor.authorKhutoryanskiy, Vitaliy V.
dc.contributor.authorKirton, Stewart B.
dc.contributor.authorMahmoudi, Najet
dc.contributor.authorMcAuley, William J.
dc.contributor.authorCook, Michael T.
dc.date.accessioned2021-12-13T11:00:03Z
dc.date.available2021-12-13T11:00:03Z
dc.date.issued2021-12-11
dc.identifier.citationHaddow , P J , da Silva , M A , Kaldybekov , D B , Dreiss , C A , Hoffman , E , Hutter , V , Khutoryanskiy , V V , Kirton , S B , Mahmoudi , N , McAuley , W J & Cook , M T 2021 , ' Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material ' , Macromolecular Bioscience . https://doi.org/10.1002/mabi.202100432
dc.identifier.issn1616-5187
dc.identifier.otherPURE: 26410372
dc.identifier.otherPURE UUID: 86b5d575-29d4-4d61-b945-9686befc06e9
dc.identifier.otherJisc: dcdcb084e30148dfa65b7c297e2e463c
dc.identifier.otherJisc: dcdcb084e30148dfa65b7c297e2e463c
dc.identifier.otherpublisher-id: mabi202100432
dc.identifier.otherORCID: /0000-0002-7998-924X/work/104970582
dc.identifier.otherScopus: 85120884652
dc.identifier.urihttp://hdl.handle.net/2299/25247
dc.description© 2021 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License. https://creativecommons.org/licenses/by/4.0/
dc.description.abstractThermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies. Poly(N,N‐diethyl acrylamide) (PDEA) is a thermoresponsive polymer which can be used as a trigger to form thermoreversible gels, however its use in these materials is limited and crucial design principles are unknown. Herein ABA copolymers with the structure PDEA‐b‐poly(ethylene glycol) (PEG)‐b‐PDEA are synthesized to give four block copolymers with varied molecular weight of PDEA and PEG blocks. Rheometry on solutions of the block copolymers reveals that high molecular weight PEG blocks are required to form thermoreversible gels with predominantly solid‐like behavior. Furthermore, small‐angle X‐ray scattering elucidates clear differences in the nanostructure of the copolymer library which can be linked to distinct rheological behaviors. A thermoreversible gel formulation based on PDEA (20 kDa)‐b‐PEG (10 kDa)‐b‐PDEA (20 kDa) is designed by optimizing the polymer concentration and ionic strength. It is found that the gel is mucoadhesive, stable, and non‐toxic, as well as giving controlled release of a hydrophobic drug. Overall, this study provides insight into the effect of polymer architecture on the nanostructure and rheology of PDEA‐b‐PEG‐b‐PDEA and presents the development of a highly functional thermoreversible gel with high promise for healthcare applications.en
dc.format.extent13
dc.language.isoeng
dc.relation.ispartofMacromolecular Bioscience
dc.rightsOpen
dc.subjectResearch Article
dc.subjectResearch Articles
dc.subjectdrug delivery
dc.subjecthydrogel
dc.subjectin situ gels
dc.subjectmucoadhesion
dc.subjectstimuli‐responsive polymers
dc.titlePolymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Materialen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionToxicology
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionNatural Product Chemistry and Drug Design
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dc.description.versiontypeFinal Published version
dcterms.dateAccepted2021-12-11
rioxxterms.versionVoR
rioxxterms.versionofrecordhttps://doi.org/10.1002/mabi.202100432
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeOpen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record