dc.contributor.author | Antrobus, M | |
dc.contributor.author | Brazier, Jon | |
dc.contributor.author | Callus, P | |
dc.contributor.author | Herbert, A | |
dc.contributor.author | Stebbings, G | |
dc.contributor.author | Day, S | |
dc.contributor.author | Kilduff, L | |
dc.contributor.author | Bennett, M | |
dc.contributor.author | Erskine, R | |
dc.contributor.author | Raleigh, Stuart | |
dc.contributor.author | Collins, M. | |
dc.contributor.author | Pitsiladis, Y | |
dc.contributor.author | Heffernan, S | |
dc.contributor.author | Williams, A | |
dc.date.accessioned | 2022-04-01T11:15:04Z | |
dc.date.available | 2022-04-01T11:15:04Z | |
dc.date.issued | 2023-09-01 | |
dc.identifier.citation | Antrobus , M , Brazier , J , Callus , P , Herbert , A , Stebbings , G , Day , S , Kilduff , L , Bennett , M , Erskine , R , Raleigh , S , Collins , M , Pitsiladis , Y , Heffernan , S & Williams , A 2023 , ' Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status ' , Clinical Journal of Sport Medicine , vol. 33 , no. 5 , pp. 145-151 . https://doi.org/10.1097/JSM.0000000000001030 | |
dc.identifier.issn | 1050-642X | |
dc.identifier.other | ORCID: /0000-0002-4104-9447/work/159376035 | |
dc.identifier.uri | http://hdl.handle.net/2299/25453 | |
dc.description | © 2022 Wolters Kluwer Health, Inc. All rights reserved. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1097/JSM.0000000000001030 | |
dc.description.abstract | Objective: Concussions are common match injuries in elite rugby and reports exist of reduced cognitive function and long-term health consequences that can interrupt or end a playing career and produce continued ill health. The aim of this study was to investigate the association between elite rugby status and eight concussion-associated risk polymorphisms. We hypothesized that concussion-associated risk genotypes and alleles would be underrepresented in elite rugby athletes compared to non-athletes. Design: A case-control genetic association study. Setting: Institutional (university). Participants: Elite Caucasian male rugby athletes (n = 668, mean (standard deviation) height 1.85 (0.07) m, mass 102 (12) kg, age 29 (7) yr) and 1015 non-athlete Caucasian men and women (48% men). Interventions: Genotype was the independent variable, obtained via PCR of genomic DNA using TaqMan probes. Main Outcome Measure: Elite athlete status, with groups compared using χ2 and odds ratio. Results: The COMT rs4680 Met/Met (AA) genotype, Met allele possession and Met allele frequency were lower in rugby athletes (24.8%, 74.6% and 49.7%, respectively) than non-athletes (30.2%, 77.6%, and 54.0%; P < 0.05). The Val/Val (GG) genotype was more common in elite rugby athletes than non-athletes (odds ratio 1.39, 95% confidence interval 1.04-1.86). No other polymorphism was associated with elite athlete status. Conclusions: Elite rugby athlete status is associated with COMT rs4680 genotype that, acting pleiotropically, could affect stress resilience and behavioral traits during competition, concussion risk and/or recovery from concussion. Consequently, assessing COMT rs4680 genotype might aid future individualized management of concussion risk amongst athletes. | en |
dc.format.extent | 7 | |
dc.format.extent | 488835 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Journal of Sport Medicine | |
dc.title | Concussion-associated gene variant COMT rs4680 is associated with elite rugby athlete status | en |
dc.contributor.institution | Centre for Research in Psychology and Sports | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Psychology, Sport and Geography | |
dc.contributor.institution | High Performance Sport Research Group | |
dc.contributor.institution | Exercise, Health and Wellbeing Research Group | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2023-03-29 | |
rioxxterms.versionofrecord | 10.1097/JSM.0000000000001030 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |