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        The effect of alterations of schizophrenia-associated genes on gamma band oscillations

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        Author
        Metzner, Christoph
        Mäki-Marttunen, Tuomo
        Karni, Gili
        McMahon-Cole, Hana
        Steuber, Volker
        Attention
        2299/25511
        Abstract
        Abnormalities in the synchronized oscillatory activity of neurons in general and, specifically in the gamma band, might play a crucial role in the pathophysiology of schizophrenia. While these changes in oscillatory activity have traditionally been linked to alterations at the synaptic level, we demonstrate here, using computational modeling, that common genetic variants of ion channels can contribute strongly to this effect. Our model of primary auditory cortex highlights multiple schizophrenia-associated genetic variants that reduce gamma power in an auditory steady-state response task. Furthermore, we show that combinations of several of these schizophrenia-associated variants can produce similar effects as the more traditionally considered synaptic changes. Overall, our study provides a mechanistic link between schizophrenia-associated common genetic variants, as identified by genome-wide association studies, and one of the most robust neurophysiological endophenotypes of schizophrenia.
        Publication date
        2022-04-28
        Published in
        Schizophrenia
        Published version
        https://doi.org/10.1038/s41537-022-00255-7
        License
        http://creativecommons.org/licenses/by/4.0/
        Other links
        http://hdl.handle.net/2299/25511
        Relations
        School of Physics, Engineering & Computer Science
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