dc.contributor.author | Antrobus, Mark R. | |
dc.contributor.author | Brazier, Jon | |
dc.contributor.author | Callus, Peter C. | |
dc.contributor.author | Herbert, Adam J. | |
dc.contributor.author | Stebbings, Georgina K. | |
dc.contributor.author | Khanal, Praval | |
dc.contributor.author | Day, Stephen H. | |
dc.contributor.author | Kilduff, Liam P. | |
dc.contributor.author | Bennett, Mark A. | |
dc.contributor.author | Erskine, Robert M. | |
dc.contributor.author | Raleigh, Stuart M. | |
dc.contributor.author | Collins, Malcolm | |
dc.contributor.author | Pitsiladis, Yannis P. | |
dc.contributor.author | Heffernan, Shane M. | |
dc.contributor.author | Williams, Alun G. | |
dc.date.accessioned | 2022-05-23T13:30:01Z | |
dc.date.available | 2022-05-23T13:30:01Z | |
dc.date.issued | 2022-05-04 | |
dc.identifier.citation | Antrobus , M R , Brazier , J , Callus , P C , Herbert , A J , Stebbings , G K , Khanal , P , Day , S H , Kilduff , L P , Bennett , M A , Erskine , R M , Raleigh , S M , Collins , M , Pitsiladis , Y P , Heffernan , S M & Williams , A G 2022 , ' Concussion-Associated Polygenic Profiles of Elite Male Rugby Athletes ' , Genes , vol. 13 , no. 5 , e820 . https://doi.org/10.3390/genes13050820 | |
dc.identifier.issn | 2073-4425 | |
dc.identifier.other | Jisc: 294168 | |
dc.identifier.other | Jisc: 294168 | |
dc.identifier.uri | http://hdl.handle.net/2299/25516 | |
dc.description | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |
dc.description.abstract | Due to the high-velocity collision-based nature of elite rugby league and union, the risk of sustaining a concussion is high. Occurrence of and outcomes following a concussion are probably affected by the interaction of multiple genes in a polygenic manner. This study investigated whether suspected concussion-associated polygenic profiles of elite rugby athletes differed from non-athletes and between rugby union forwards and backs. We hypothesised that a total genotype score (TGS) using eight concussion-associated polymorphisms would be higher in elite rugby athletes than non-athletes, indicating selection for protection against incurring or suffering prolonged effects of, concussion in the relatively high-risk environment of competitive rugby. In addition, multifactor dimensionality reduction was used to identify genetic interactions. Contrary to our hypothesis, TGS did not differ between elite rugby athletes and non-athletes (p ≥ 0.065), nor between rugby union forwards and backs (p = 0.668). Accordingly, the TGS could not discriminate between elite rugby athletes and non-athletes (AUC ~0.5), suggesting that, for the eight polymorphisms investigated, elite rugby athletes do not have a more ‘preferable’ concussion-associated polygenic profile than non-athletes. However, the COMT (rs4680) and MAPT (rs10445337) GC allele combination was more common in rugby athletes (31.7%; p 0.001) and rugby union athletes (31.8%; p 0.001) than non-athletes (24.5%). Our results thus suggest a genetic interaction between COMT (rs4680) and MAPT (rs10445337) assists rugby athletes in achieving elite status. These findings need exploration vis-à-vis sport-related concussion injury data and could have implications for the management of inter-individual differences in concussion risk. | en |
dc.format.extent | 13 | |
dc.format.extent | 1222907 | |
dc.language.iso | eng | |
dc.relation.ispartof | Genes | |
dc.subject | rugby | |
dc.subject | genotype | |
dc.subject | concussion | |
dc.subject | brain | |
dc.subject | polymorphism | |
dc.subject | genetics | |
dc.title | Concussion-Associated Polygenic Profiles of Elite Male Rugby Athletes | en |
dc.contributor.institution | Department of Psychology, Sport and Geography | |
dc.contributor.institution | Centre for Research in Psychology and Sport Sciences | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | High Performance Sport Research Group | |
dc.contributor.institution | Exercise, Health and Wellbeing Research Group | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.3390/genes13050820 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |