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        Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: An European and Asia-Pacific Expert Consensus Paper

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        Assessment_of_bleeding_risk.pdf (PDF, 613Kb)(embargoed until 22/03/2023)
        Author
        Gorog, Diana
        Gue, Ying X.
        Chao, Tze-Fan
        Fauchier, Laurent
        Ferreiro, Jose Luis
        Huber, Kurt
        Konstantinidis, Stavros V
        Lane, Deirdre A
        Marin, Francisco
        Oldgren, Jonas
        Potpara, Tatjana
        Roldan, Vanessa
        Rubboli, Andrea
        Sibbing, Dirk
        Tse, Hung-Fat
        Vilahur, Gemma
        Lip, Gregory Y H
        Attention
        2299/25543
        Abstract
        Whilst there is a clear clinical benefit of oral anticoagulation (OAC) in patients with atrial fibrillation (AF) and venous thromboembolism (VTE) in reducing the risks of thromboembolism, major bleeding events (especially intracranial bleeds) may still occur and be devastating. The decision for initiating and continuing anticoagulation is often based on a careful assessment of both thromboembolism- and bleeding- risk. The more common and validated bleeding risk factors have been used to formulate bleeding risk stratification scores, but thromboembolism and bleeding risk factors often overlap. Also, many factors that increase bleeding risk are transient and modifiable, such as variable INR values, surgical procedures, vascular procedures, or drug-drug and food-drug interactions. Bleeding risk is also not a static ‘one off’ assessment based on baseline factors but is dynamic, being influenced by ageing, incident comorbidities and drug therapies. In this executive summary of our Consensus Document, we comprehensively review the published evidence and propose a consensus on bleeding risk assessments in patients with AF and VTE, with a view to summarising ‘best practice’ when approaching antithrombotic therapy in these patients. We address the epidemiology and size of the problem of bleeding risk in AF and VTE, and review established bleeding risk factors and summarise definitions of bleeding. Patient values and preferences, balancing the risk of bleeding against thromboembolism are reviewed, and the prognostic implications of bleeding are discussed. We propose consensus statements that may help to define evidence gaps and assist in everyday clinical practice.
        Publication date
        2022-03-22
        Published in
        Thrombosis and haemostasis
        Published version
        https://doi.org/10.1093/europace/euac020
        Other links
        http://hdl.handle.net/2299/25543
        Relations
        School of Life and Medical Sciences
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