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dc.contributor.authorShepherd, Victoria
dc.contributor.authorIslam, Ishrat
dc.contributor.authorWood, Fiona
dc.contributor.authorWilliamson, Paula R.
dc.contributor.authorGoodman, Claire
dc.contributor.authorBath, Philip M.
dc.contributor.authorThompson, Carl
dc.contributor.authorKnapp, Martin
dc.contributor.authorGordon, Adam L.
dc.contributor.authorHood, Kerenza
dc.date.accessioned2022-09-05T16:00:01Z
dc.date.available2022-09-05T16:00:01Z
dc.date.issued2022-08-27
dc.identifier.citationShepherd , V , Islam , I , Wood , F , Williamson , P R , Goodman , C , Bath , P M , Thompson , C , Knapp , M , Gordon , A L & Hood , K 2022 , ' Development of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study) ' , BMC Geriatrics , vol. 22 , 710 . https://doi.org/10.1186/s12877-022-03395-8
dc.identifier.issn1471-2318
dc.identifier.otherJisc: 564210
dc.identifier.otherJisc: 564210
dc.identifier.otherpublisher-id: s12877-022-03395-8
dc.identifier.othermanuscript: 3395
dc.identifier.urihttp://hdl.handle.net/2299/25748
dc.description© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.description.abstractAbstract: Background: People living in care homes have experienced devastating impact from COVID-19. As interventions to prevent the transmission of COVID-19 are developed and evaluated, there is an urgent need for researchers to agree on the outcomes used when evaluating their effectiveness. Having an agreed set of outcomes that are used in all relevant trials can ensure that study results can be compared. Objective: The aim of the study was to develop a core outcome set (COS) for trials assessing the effectiveness of pharmacological and non-pharmacological interventions for preventing COVID-19 infection and transmission in care homes. Methods: The study used established COS methodology. A list of candidate outcomes was identified by reviewing registered trials to evaluate interventions to prevent COVID-19 in care homes. Seventy key stakeholders participated in a Delphi survey, rating the candidate outcomes on a nine-point scale over two rounds, with the opportunity to propose additional outcomes. Stakeholders included care home representatives (n = 19), healthcare professionals (n = 20), people with personal experience of care homes (n = 7), researchers (n = 15) and others (n = 9). Outcomes were eligible for inclusion if they met an a priori threshold. A consensus meeting with stakeholders resulted in agreement of the final outcome set. Results: Following the Delphi and consensus meeting, twenty-four outcomes were recommended for inclusion. These are grouped across four domains of infection, severity of illness, mortality, and ‘other’ (intervention specific or life impact). Due to the considerable heterogeneity between care homes, residents, and interventions, the relevance and importance of outcomes may differ between trial contexts. Intervention-specific outcomes would be included only where relevant to a given trial, thus reducing the measurement burden. Conclusion: Using a rapid response approach, a COS for COVID-19 prevention interventions in care homes has been developed. Future work should focus on identifying instruments for measuring these outcomes, and the interpretation and application of the COS across different trial contexts. Beyond COVID-19, the outcomes identified in this COS may have relevance to other infectious diseases in care homes, and the rapid response approach may be useful as preparation for future pandemics.en
dc.format.extent1282582
dc.language.isoeng
dc.relation.ispartofBMC Geriatrics
dc.subjectResearch
dc.subjectCare homes
dc.subjectCOVID-19
dc.subjectPandemic
dc.subjectPrevention
dc.subjectCore outcome set
dc.titleDevelopment of a core outcome set for the evaluation of interventions to prevent COVID-19 in care homes (COS-COVID-PCARE Study)en
dc.contributor.institutionSchool of Health and Social Work
dc.contributor.institutionOlder People's Health and Complex Conditions
dc.contributor.institutionCentre for Research in Public Health and Community Care
dc.description.statusPeer reviewed
dc.identifier.urlhttps://www.researchsquare.com/article/rs-1536186/v1
rioxxterms.versionofrecord10.1186/s12877-022-03395-8
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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