dc.contributor.author | Bassin, Jatinder | |
dc.contributor.author | Dimitriadi, Maria | |
dc.contributor.author | Cook, Michael T. | |
dc.contributor.author | Abelha, Thais Fedatto | |
dc.contributor.author | Calvo-Castro, Jesus | |
dc.date.accessioned | 2022-09-21T16:00:05Z | |
dc.date.available | 2022-09-21T16:00:05Z | |
dc.date.issued | 2022-12-27 | |
dc.identifier.citation | Bassin , J , Dimitriadi , M , Cook , M T , Abelha , T F & Calvo-Castro , J 2022 , ' Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review ' , Chemistry - A European Journal , vol. 28 , no. 72 , e202202366 , pp. 1-31 . https://doi.org/10.1002/chem.202202366 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.other | ORCID: /0000-0003-1031-8648/work/119582621 | |
dc.identifier.other | Jisc: 683924 | |
dc.identifier.uri | http://hdl.handle.net/2299/25772 | |
dc.description | © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/ | |
dc.description.abstract | Abstract: The last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical role in a number of key biological processes, including cellular metabolism. Importantly, irregularities on their working function are nowadays understood to be intimately linked to a range of clinical conditions, highlighting the importance of targeting mitochondria for therapeutic benefits. In this work we carry out an in‐depth evaluation on the progress to date in the field to pave the way for the realization of superior alternatives to those currently existing. The manuscript is structured by commonly used chemical scaffolds and comprehensively covers key aspects factored in design strategies such as synthetic approaches as well as photophysical and biological characterization, to foster collaborative work among organic and physical chemists as well as cell biologists. | en |
dc.format.extent | 35 | |
dc.format.extent | 12189072 | |
dc.language.iso | eng | |
dc.relation.ispartof | Chemistry - A European Journal | |
dc.subject | bioimaging | |
dc.subject | fluorescence | |
dc.subject | mitochondria | |
dc.subject | optoelectronics | |
dc.subject | organic materials | |
dc.subject | Reviews | |
dc.subject | Review | |
dc.subject | Catalysis | |
dc.subject | Organic Chemistry | |
dc.title | Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review | en |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Centre for Future Societies Research | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=85141176230&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1002/chem.202202366 | |
rioxxterms.type | Other | |
herts.preservation.rarelyaccessed | true | |