Show simple item record

dc.contributor.authorBassin, Jatinder
dc.contributor.authorDimitriadi, Maria
dc.contributor.authorCook, Michael T.
dc.contributor.authorAbelha, Thais Fedatto
dc.contributor.authorCalvo-Castro, Jesus
dc.date.accessioned2022-09-21T16:00:05Z
dc.date.available2022-09-21T16:00:05Z
dc.date.issued2022-09-19
dc.identifier.citationBassin , J , Dimitriadi , M , Cook , M T , Abelha , T F & Calvo-Castro , J 2022 , ' Mitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Review ' , Chemistry - A European Journal . https://doi.org/10.1002/chem.202202366
dc.identifier.issn1521-3765
dc.identifier.otherPURE: 31762460
dc.identifier.otherPURE UUID: 66d16ecc-641f-4d3a-8df1-b1b6bd46b2f9
dc.identifier.otherORCID: /0000-0003-1031-8648/work/119582621
dc.identifier.urihttp://hdl.handle.net/2299/25772
dc.description© 2022 Wiley-VCH GmbH. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1002/chem.202202366
dc.description.abstractThe last decade has seen an increasingly large number of studies reporting on the development of novel small organic conjugated systems for mitochondrial imaging exploiting optical signal transduction pathways. Mitochondria are known to play a critical role in a number of key biological processes, including cellular metabolism. Importantly, irregularities on their working function are nowadays understood to be intimately linked to a range of clinical conditions, highlighting the importance of targeting mitochondria for therapeutic benefits. In this work we carry out an in-depth evaluation on the progress to date in the field to pave the way for the realization of superior alternatives to those currently existing. The manuscript is structured by commonly used chemical scaffolds and comprehensively covers key aspects factored in design strategies such as synthetic approaches as well as photophysical and biological characterization, to foster collaborative work among organic and physical chemists as well as cell biologists.en
dc.format.extent35
dc.language.isoeng
dc.relation.ispartofChemistry - A European Journal
dc.titleMitochondrial Targeting and Imaging with Small Organic Conjugated Fluorophores: A Reviewen
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.description.statusPeer reviewed
dc.date.embargoedUntil2023-09-19
rioxxterms.versionAM
rioxxterms.versionofrecordhttps://doi.org/10.1002/chem.202202366
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record