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A Genomic Regulatory Network for Development

dc.contributor.authorDavidson, E.H.
dc.contributor.authorRast, J.P.
dc.contributor.authorOliveri, P.
dc.contributor.authorRansick, A.
dc.contributor.authorCalestani, C.
dc.contributor.authorYuh, C.H.
dc.contributor.authorMinokawa, T.
dc.contributor.authorAmore, G.
dc.contributor.authorHinman, V.
dc.contributor.authorArenas-Mena, C.
dc.contributor.authorOtim, A.
dc.contributor.authorBrown, C.T.
dc.contributor.authorLivi, C.B.
dc.contributor.authorLee, P.Y.
dc.contributor.authorRevilla, R.
dc.contributor.authorRust, A.G.
dc.contributor.authorPan, Z.
dc.contributor.authorSchilstra, M.
dc.contributor.authorClarke, P.J.C.
dc.contributor.authorArnone, M.I.
dc.contributor.authorRowen, L.
dc.contributor.authorCameron, R.A.
dc.contributor.authorMcClay, D.R.
dc.contributor.authorHood, L.
dc.contributor.authorBolouri, H.
dc.date.accessioned2008-11-14T11:53:50Z
dc.date.available2008-11-14T11:53:50Z
dc.date.issued2002
dc.identifier.citationDavidson , E H , Rast , J P , Oliveri , P , Ransick , A , Calestani , C , Yuh , C H , Minokawa , T , Amore , G , Hinman , V , Arenas-Mena , C , Otim , A , Brown , C T , Livi , C B , Lee , P Y , Revilla , R , Rust , A G , Pan , Z , Schilstra , M , Clarke , P J C , Arnone , M I , Rowen , L , Cameron , R A , McClay , D R , Hood , L & Bolouri , H 2002 , ' A Genomic Regulatory Network for Development ' , Science , vol. 295 , no. 5560 , pp. 1669-1678 . https://doi.org/10.1126/science.1069883
dc.identifier.issn0036-8075
dc.identifier.otherPURE: 99794
dc.identifier.otherPURE UUID: ce511dc9-4d68-4a52-9f5a-41548df04598
dc.identifier.otherdspace: 2299/2605
dc.identifier.otherScopus: 0036500609
dc.identifier.urihttp://hdl.handle.net/2299/2605
dc.descriptionOriginal article can be found at: http://www.sciencemag.org/ Copyright American Association for the Advancement of Science. [Full text of this article is not available in the UHRA]
dc.description.abstractDevelopment of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.en
dc.language.isoeng
dc.relation.ispartofScience
dc.titleA Genomic Regulatory Network for Developmenten
dc.contributor.institutionSchool of Computer Science
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1126/science.1069883
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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