dc.contributor.author | Mustafov, Denis | |
dc.contributor.author | Karteris, Emmanouil | |
dc.contributor.author | Braoudaki, Maria | |
dc.date.accessioned | 2023-02-28T15:30:02Z | |
dc.date.available | 2023-02-28T15:30:02Z | |
dc.date.issued | 2023-01-04 | |
dc.identifier.citation | Mustafov , D , Karteris , E & Braoudaki , M 2023 , ' Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis ' , Non-Coding RNA , vol. 9 , no. 1 . https://doi.org/10.3390/ncrna9010004 | |
dc.identifier.other | Jisc: 882089 | |
dc.identifier.uri | http://hdl.handle.net/2299/26096 | |
dc.description | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/) | |
dc.description.abstract | Glioblastoma multiforme (GBM) is a highly heterogenic and malignant brain tumour with a median survival of 15 months. The initial identification of primary glioblastomas is often challenging. Coronin 1C (CORO1C) is a key player in actin rearrangement and cofilin dynamics, as well as enhancing the processes of neurite overgrowth and migration of brain tumour cells. Different bioinformatic databases were accessed to measure CORO1C expression at the mRNA and protein level in normal and malignant brains. CORO1C expression was observed in brain regions which have retained high synaptic plasticity and myelination properties. CORO1C was also expressed mainly within the hippocampus formation, including the Cornu Ammonis (CA) fields: CA1-CA4. Higher expression was also noticed in paediatric GBM in comparison to their adult counterparts. Pediatric cell populations were observed to have an increased log2 expression of CORO1C. Furthermore, 62 miRNAs were found to target the CORO1C gene. Of these, hsa-miR-34a-5p, hsa-miR-512-3p, hsa-miR-136-5p, hsa-miR-206, hsa-miR-128-3p, and hsa-miR-21-5p have shown to act as tumour suppressors or oncomiRs in different neoplasms, including GBM. The elevated expression of CORO1C in high grade metastatic brain malignancies, including GBM, suggests that this protein could have a clinical utility as a biomarker linked to an unfavorable outcome. | en |
dc.format.extent | 18 | |
dc.format.extent | 1862407 | |
dc.language.iso | eng | |
dc.relation.ispartof | Non-Coding RNA | |
dc.subject | Article | |
dc.subject | CORO1C | |
dc.subject | adult | |
dc.subject | brain | |
dc.subject | cancer | |
dc.subject | glioblastoma | |
dc.subject | mRNA | |
dc.subject | microRNA expression | |
dc.subject | pediatric | |
dc.title | Deciphering the Role of microRNA Mediated Regulation of Coronin 1C in Glioblastoma Development and Metastasis | en |
dc.contributor.institution | Centre for Future Societies Research | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Biosciences Research Group | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.3390/ncrna9010004 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |