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dc.contributor.authorYouness, Rana Ahmed
dc.contributor.authorAl-Mahallawi, Abdulaziz Mohsen
dc.contributor.authorMahmoud, Farah Haytham
dc.contributor.authorAtta, Hind
dc.contributor.authorBraoudaki, Maria
dc.contributor.authorFahmy, Sherif Ashraf
dc.contributor.editorMarin, Luminita
dc.contributor.editorDing, Jianxun
dc.date.accessioned2023-04-11T17:15:02Z
dc.date.available2023-04-11T17:15:02Z
dc.date.issued2023-03-15
dc.identifier.citationYouness , R A , Al-Mahallawi , A M , Mahmoud , F H , Atta , H , Braoudaki , M , Fahmy , S A , Marin , L (ed.) & Ding , J (ed.) 2023 , ' Oral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cells ' , Polymers , vol. 15 , no. 6 , 1464 , pp. 1-16 . https://doi.org/10.3390/polym15061464
dc.identifier.issn2073-4360
dc.identifier.otherJisc: 1003552
dc.identifier.otherpublisher-id: polymers-15-01464
dc.identifier.urihttp://hdl.handle.net/2299/26159
dc.description© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractThis study aims to design and optimize chitosan-coated bilosomal formulations loaded with psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and boosted apoptotic and necrotic effects. In this regard, uncoated bilosomes loaded with Ps (Ps/BLs) were nanoformulated using the thin-film hydration technique using different molar ratios of phosphatidylcholine (PC), cholesterol (Ch), Span 60 (S60), and sodium deoxycholate (SDC) (1:0.4:0.2:0.125, 1:0.4:0.2:0.25, and 1:0.4:0.2:0.5, respectively). The best-optimized formulation with respect to size, PDI, zeta potential, and EE% was selected and then coated with chitosan at two different concentrations (0.125 and 0.25 w/v%), forming Ps-CS/BLs. The optimized Ps/BLs and Ps-CS/BLs showed a spherical shape and relatively homogenous size with negligible apparent agglomerations. Additionally, it was demonstrated that coating Ps/BLs with chitosan has significantly increased the particle size from 123.16 ± 6.90 in the case of Ps/BLs to 183.90 ± 15.93 nm in the case of Ps-CS/BLs. In addition, Ps-CS/BLs exhibited higher zeta potential (+30.78 ± 1.44 mV) as compared to Ps/BLs (−18.59 ± 2.13 mV). Furthermore, Ps-CS/BL showed enhanced entrapment efficiency (EE%) of 92.15 ± 7.20% as compared to Ps/BLs (68.90 ± 5.95%). Moreover, Ps-CS/BLs exhibited a more sustained release behavior of Ps compared to Ps/BLs over 48 h, and both formulations were best obeying the Higuchi diffusion model. More importantly, Ps-CS/BLs displayed the highest mucoadhesive efficiency% (74.89 ± 3.5%) as compared to Ps/BLs (26.78 ± 2.9%), indicating the ability of the designed nanoformulation to improve oral bioavailability and extend the residence time inside the gastrointestinal tract upon oral administration. Moreover, upon evaluating the apoptotic and necrotic effects of free Ps and Ps-CS/BLs on human breast cancer cell lines (MCF-7) and human lung adenocarcinoma cell lines (A549), there was a dramatic increase in the percentages of the apoptotic and necrotic cell compared to the control and free Ps. Our findings suggest the possible oral use of Ps-CS/BLs in hampering breast and lung cancers.en
dc.format.extent16
dc.format.extent3334000
dc.language.isoeng
dc.relation.ispartofPolymers
dc.subjectArticle
dc.subjectpsoralidin
dc.subjectchitosan
dc.subjectbilosomes
dc.subjectoral delivery
dc.subjectapoptosis
dc.subjectbreast cancer
dc.subjectlung cancer
dc.subjectGeneral Chemistry
dc.subjectPolymers and Plastics
dc.titleOral Delivery of Psoralidin by Mucoadhesive Surface-Modified Bilosomes Showed Boosted Apoptotic and Necrotic Effects against Breast and Lung Cancer Cellsen
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionBiosciences Research Group
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85151613929&partnerID=8YFLogxK
rioxxterms.versionofrecord10.3390/polym15061464
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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