dc.contributor.author | Rossiter, S. | |
dc.contributor.author | Smith, C.L. | |
dc.contributor.author | Malaki, M. | |
dc.contributor.author | Nandi, M. | |
dc.contributor.author | Gill, H. | |
dc.contributor.author | Leiper, J.M. | |
dc.contributor.author | Vallance, P. | |
dc.contributor.author | Selwood, D.L. | |
dc.date.accessioned | 2008-11-18T10:08:22Z | |
dc.date.available | 2008-11-18T10:08:22Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Rossiter , S , Smith , C L , Malaki , M , Nandi , M , Gill , H , Leiper , J M , Vallance , P & Selwood , D L 2005 , ' Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase ' , Journal of Medicinal Chemistry , vol. 48 , no. 14 , pp. 4670-4678 . https://doi.org/10.1021/jm050187a | |
dc.identifier.issn | 0022-2623 | |
dc.identifier.other | dspace: 2299/2619 | |
dc.identifier.other | ORCID: /0000-0003-3822-0028/work/142009573 | |
dc.identifier.uri | http://hdl.handle.net/2299/2619 | |
dc.description | Original article can be found at: http://pubs.acs.org/journal/jmcmar Copyright American Chemical Society DOI: 10.1021/jm050187a [Full text of this article is not available in the UHRA] | |
dc.description.abstract | The enzyme DDAH metabolizes methylarginines that are inhibitors of nitric oxide synthase (NOS). Substrate-based inhibitors of mammalian DDAH have been synthesized, with optimization to give selective inhibition of DDAH with no significant direct effect on NOSs. These are the first examples of reversible DDAH inhibitors with significant activity and selectivity. In vivo administration increases plasma ADMA levels, giving proof of concept that these inhibitors can be used to probe the physiological effects of DDAH inhibition, with potential for pharmaceutical use of DDAH inhibitors in diseases where excess NO production is implicated. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Medicinal Chemistry | |
dc.title | Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase | en |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
dc.contributor.institution | Natural Product Chemistry and Drug Design | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1021/jm050187a | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |