| dc.contributor.author | Rossiter, S. | |
| dc.contributor.author | Woo, C.K. | |
| dc.contributor.author | Hartzoulakis, B. | |
| dc.contributor.author | Wishart, G. | |
| dc.contributor.author | Stanyer, L. | |
| dc.contributor.author | Labadie, J.W. | |
| dc.contributor.author | Selwood, D.L. | |
| dc.date.accessioned | 2008-11-18T13:44:21Z | |
| dc.date.available | 2008-11-18T13:44:21Z | |
| dc.date.issued | 2004 | |
| dc.identifier.citation | Rossiter , S , Woo , C K , Hartzoulakis , B , Wishart , G , Stanyer , L , Labadie , J W & Selwood , D L 2004 , ' Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries ' , Journal of Combinatorial Chemistry , vol. 6 , no. 3 , pp. 385-390 . https://doi.org/10.1021/cc034065k | |
| dc.identifier.issn | 1520-4766 | |
| dc.identifier.other | dspace: 2299/2621 | |
| dc.identifier.other | ORCID: /0000-0003-3822-0028/work/142009576 | |
| dc.identifier.uri | http://hdl.handle.net/2299/2621 | |
| dc.description | Original article can be found at: http://pubs.acs.org/journal/jcchff Copyright American Chemical Society DOI: 10.1021/cc034065k [Full text of this article is not available in the UHRA] | |
| dc.description.abstract | A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. Cupric acetate-mediated N-arylation with aryl boronic acids proceeded regioselectively to form the N-2-substituted derivatives. The presence of the 3-dimethylaminopropyloxy group was found to completely control the regioselectivity of the arylation. Presence of a dimethylaminoethyloxy or dimethylaminobutyloxy group gave a lesser degree of regioselectivity. The scope of the method as applied to library synthesis is discussed. | en |
| dc.language.iso | eng | |
| dc.relation.ispartof | Journal of Combinatorial Chemistry | |
| dc.title | Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries | en |
| dc.contributor.institution | Department of Pharmacy | |
| dc.contributor.institution | Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit | |
| dc.contributor.institution | Centre for Research in Mechanisms of Disease and Drug Discovery | |
| dc.contributor.institution | Natural Product Chemistry and Drug Design | |
| dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
| dc.contributor.institution | Centre for Health Services and Clinical Research | |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.description.status | Peer reviewed | |
| rioxxterms.versionofrecord | 10.1021/cc034065k | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
