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dc.contributor.authorRossiter, S.
dc.contributor.authorWoo, C.K.
dc.contributor.authorHartzoulakis, B.
dc.contributor.authorWishart, G.
dc.contributor.authorStanyer, L.
dc.contributor.authorLabadie, J.W.
dc.contributor.authorSelwood, D.L.
dc.date.accessioned2008-11-18T13:44:21Z
dc.date.available2008-11-18T13:44:21Z
dc.date.issued2004
dc.identifier.citationRossiter , S , Woo , C K , Hartzoulakis , B , Wishart , G , Stanyer , L , Labadie , J W & Selwood , D L 2004 , ' Copper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole libraries ' , Journal of Combinatorial Chemistry , vol. 6 , no. 3 , pp. 385-390 . https://doi.org/10.1021/cc034065k
dc.identifier.issn1520-4766
dc.identifier.otherdspace: 2299/2621
dc.identifier.otherORCID: /0000-0003-3822-0028/work/142009576
dc.identifier.urihttp://hdl.handle.net/2299/2621
dc.descriptionOriginal article can be found at: http://pubs.acs.org/journal/jcchff Copyright American Chemical Society DOI: 10.1021/cc034065k [Full text of this article is not available in the UHRA]
dc.description.abstractA N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. Cupric acetate-mediated N-arylation with aryl boronic acids proceeded regioselectively to form the N-2-substituted derivatives. The presence of the 3-dimethylaminopropyloxy group was found to completely control the regioselectivity of the arylation. Presence of a dimethylaminoethyloxy or dimethylaminobutyloxy group gave a lesser degree of regioselectivity. The scope of the method as applied to library synthesis is discussed.en
dc.language.isoeng
dc.relation.ispartofJournal of Combinatorial Chemistry
dc.titleCopper (II) mediated arylation with aryl boronic acids for the N-derivatization of pyrazole librariesen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionPsychopharmacology, Drug Misuse and Novel Psychoactive Substances Unit
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.contributor.institutionNatural Product Chemistry and Drug Design
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1021/cc034065k
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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