dc.contributor.author | Noel, Jonathan | |
dc.contributor.author | Spencer, Neil | |
dc.contributor.author | Lodia, Siya | |
dc.contributor.author | Karim, Seiver | |
dc.contributor.author | Taneja, Surina | |
dc.contributor.author | Moghanchizadeh, Darius | |
dc.contributor.author | Nayak, Arvind | |
dc.contributor.author | Tamhankar, Ashwin | |
dc.contributor.author | Angra, Seema | |
dc.contributor.author | Swamy, Rajiv | |
dc.contributor.author | Agarwal, Samita | |
dc.contributor.author | Narula, Ashish | |
dc.contributor.author | Lane, Tim | |
dc.contributor.author | Adshead, Jim | |
dc.contributor.author | Vasdev, Nikhil | |
dc.date.accessioned | 2023-08-24T11:30:00Z | |
dc.date.available | 2023-08-24T11:30:00Z | |
dc.date.issued | 2021-10-30 | |
dc.identifier.citation | Noel , J , Spencer , N , Lodia , S , Karim , S , Taneja , S , Moghanchizadeh , D , Nayak , A , Tamhankar , A , Angra , S , Swamy , R , Agarwal , S , Narula , A , Lane , T , Adshead , J & Vasdev , N 2021 , ' Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK ' , Journal of robotic surgery , vol. 16 , pp. 951–956 . https://doi.org/10.1007/s11701-021-01324-2 | |
dc.identifier.issn | 1863-2483 | |
dc.identifier.uri | http://hdl.handle.net/2299/26605 | |
dc.description | © 2021 Springer Nature. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1007/s11701-021-01324-2 | |
dc.description.abstract | The purpose is to report the United Kingdom’s largest single-centre experience of robotically assisted laparoscopic radical prostatectomies (RALP), using the neurovascular structure-adjacent frozen-section (NeuroSAFE) technique. We describe the utilisation and outcomes of this technique. This is a retrospective study from 2012 to 2019 on 520 patients undergoing NeuroSAFE RALP at our Institution. Our Institution’s database was analysed for false-positive frozen-section (FS) margins as confirmed on paraffin histopathological analysis: functional outcomes of potency, continence, and biochemical recurrence (BCR). The median (range) of console time was 145 (90–300) min. In our cohort, positive FS was seen in 30.7% (160/520) of patients, with a confirmatory paraffin analysis in 91.8% of our patients’ cohort (147/160). The neurovascular bundles (NVBs) that underwent secondary resection contained tumour in 26.8% (43/160) of the cases. Biochemical recurrence (BCR) was 6.7% (35/520), of which FS was positive in 40% (14/35) of those cases. There were insufficient evidence of a statistical association of urinary incontinence and positive surgical margin rates according to NS or NVB resection. NeuroSAFE enables intraoperative confirmation of the oncologic safety of a NS procedure. Patients with a positive FS on NeuroSAFE can be converted to a negative surgical margin (NSM) by ipsilateral wide resection. This spared 1 in 4 men from positive margins posterolaterally in our series. Limitations are the absence of a matched contemporary cohort of NS RALP without NeuroSAFE in our centre. | en |
dc.format.extent | 353458 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of robotic surgery | |
dc.title | Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK | en |
dc.contributor.institution | Statistical Services Consulting Unit | |
dc.contributor.institution | Hertfordshire Business School | |
dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
dc.contributor.institution | Extracellular Vesicle Research Unit | |
dc.contributor.institution | Basic and Clinical Science Unit | |
dc.contributor.institution | Centre for Health Services and Clinical Research | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.description.status | Peer reviewed | |
dc.date.embargoedUntil | 2022-10-30 | |
rioxxterms.versionofrecord | 10.1007/s11701-021-01324-2 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |