Show simple item record

dc.contributor.authorOn behalf of the UroSoMe Collaborators
dc.contributor.authorLeow, Jeffrey J.
dc.contributor.authorTan, Wei Shen
dc.contributor.authorTan, Wei Phin
dc.contributor.authorTan, Teck Wei
dc.contributor.authorChan, Vinson Wai-Shun
dc.contributor.authorTikkinen, Kari A. O.
dc.contributor.authorKamat, Ashish
dc.contributor.authorSengupta, Shomik
dc.contributor.authorMeng, Maxwell V.
dc.contributor.authorShariat, Shahrokh
dc.contributor.authorRoupret, Morgan
dc.contributor.authorDecaestecker, Karel
dc.contributor.authorVasdev, Nikhil
dc.contributor.authorChong, Yew Lam
dc.contributor.authorEnikeev, Dmitry
dc.contributor.authorGiannarini, Gianluca
dc.contributor.authorFicarra, Vincenzo
dc.contributor.authorTeoh, Jeremy Yuen-Chun
dc.date.accessioned2023-08-24T16:15:02Z
dc.date.available2023-08-24T16:15:02Z
dc.date.issued2022-10-04
dc.identifier.citationOn behalf of the UroSoMe Collaborators , Leow , J J , Tan , W S , Tan , W P , Tan , T W , Chan , V W-S , Tikkinen , K A O , Kamat , A , Sengupta , S , Meng , M V , Shariat , S , Roupret , M , Decaestecker , K , Vasdev , N , Chong , Y L , Enikeev , D , Giannarini , G , Ficarra , V & Teoh , J Y-C 2022 , ' A systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyond ' , Frontiers in Surgery , vol. 9 , 879774 . https://doi.org/10.3389/fsurg.2022.879774
dc.identifier.issn2296-875X
dc.identifier.otherJisc: 667617
dc.identifier.otherJisc: 667617
dc.identifier.urihttp://hdl.handle.net/2299/26607
dc.description© 2022 Leow, Tan, Tan, Tan, Chan, Tikkinen, Kamat, Sengupta, Meng, Shariat, Roupret, Decaestecker, Vasdev, Chong, Enikeev, Giannarini, Ficarra and Teoh. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/
dc.description.abstractPurpose: The COVID-19 pandemic has led to competing strains on hospital resources and healthcare personnel. Patients with newly diagnosed invasive urothelial carcinomas of bladder (UCB) upper tract (UTUC) may experience delays to definitive radical cystectomy (RC) or radical nephro-ureterectomy (RNU) respectively. We evaluate the impact of delaying definitive surgery on survival outcomes for invasive UCB and UTUC. Methods: We searched for all studies investigating delayed urologic cancer surgery in Medline and Embase up to June 2020. A systematic review and meta-analysis was performed. Results: We identified a total of 30 studies with 32,591 patients. Across 13 studies (n = 12,201), a delay from diagnosis of bladder cancer/TURBT to RC was associated with poorer overall survival (HR 1.25, 95% CI: 1.09–1.45, p = 0.002). For patients who underwent neoadjuvant chemotherapy before RC, across the 5 studies (n = 4,316 patients), a delay between neoadjuvant chemotherapy and radical cystectomy was not found to be significantly associated with overall survival (pooled HR 1.37, 95% CI: 0.96–1.94, p = 0.08). For UTUC, 6 studies (n = 4,629) found that delay between diagnosis of UTUC to RNU was associated with poorer overall survival (pooled HR 1.55, 95% CI: 1.19–2.02, p = 0.001) and cancer-specific survival (pooled HR of 2.56, 95% CI: 1.50–4.37, p = 0.001). Limitations included between-study heterogeneity, particularly in the definitions of delay cut-off periods between diagnosis to surgery. Conclusions: A delay from diagnosis of UCB or UTUC to definitive RC or RNU was associated with poorer survival outcomes. This was not the case for patients who received neoadjuvant chemotherapy.en
dc.format.extent19
dc.format.extent163475
dc.format.extent1757594
dc.language.isoeng
dc.relation.ispartofFrontiers in Surgery
dc.subjectSurgery
dc.subjectdelay in surgery
dc.subjectdelayed treatment
dc.subjecttime-to-treatment
dc.subjecturinary bladder neoplasms
dc.subjectureteral neoplasms
dc.subjecturothelial carcinoma
dc.subjectbladder cancer
dc.subjectbladder carcinoma
dc.subjectSurgery
dc.titleA systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyonden
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionExtracellular Vesicle Research Unit
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85140878965&partnerID=8YFLogxK
rioxxterms.versionofrecord10.3389/fsurg.2022.879774
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record