| dc.contributor.author | Lee, Seung-Yul | |
| dc.contributor.author | Jeong, Young-Hoon | |
| dc.contributor.author | Ho Yun, Kyeong | |
| dc.contributor.author | Young Cho, Jae | |
| dc.contributor.author | Gorog, Diana | |
| dc.contributor.author | Angiolillo, Dominick J. | |
| dc.contributor.author | Jin Won, Kim | |
| dc.contributor.author | Jang, Yangsoo | |
| dc.date.accessioned | 2023-09-29T11:45:00Z | |
| dc.date.available | 2023-09-29T11:45:00Z | |
| dc.date.issued | 2023-08-14 | |
| dc.identifier.citation | Lee , S-Y , Jeong , Y-H , Ho Yun , K , Young Cho , J , Gorog , D , Angiolillo , D J , Jin Won , K & Jang , Y 2023 , ' P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients: The MACT Pilot Study ' , JACC: Cardiovascular Interventions , vol. 16 , no. 15 , pp. 1845-1855 . https://doi.org/10.1016/j.jcin.2023.05.035 | |
| dc.identifier.issn | 1876-7605 | |
| dc.identifier.uri | http://hdl.handle.net/2299/26789 | |
| dc.description | © 2023 by the American College of Cardiology Foundation. Published by Elsevier. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1016/j.jcin.2023.05.035 | |
| dc.description.abstract | This proof-of-concept pilot trial investigated the feasibility of ticagrelor or prasugrel P2Y12 inhibitor monotherapy combined with colchicine immediately after PCI in ACS patients. The day after PCI, aspirin was replaced with low-dose colchicine (0.6 mg daily) on ticagrelor or prasugrel maintenance. Among 200 ACS patients enrolled, stent thrombosis occurred in two patients for 3 months. High platelet reactivity assessed by VerifyNow assay was low at discharge and hs-CRP levels decreased significantly within 1 month after PCI. Accordingly, P2Y12 inhibitor mono antiplatelet and colchicine therapy is feasible in ACS patients undergoing PCI and associated with favorable platelet function and inflammatory profiles. | en |
| dc.format.extent | 11 | |
| dc.format.extent | 1824373 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | JACC: Cardiovascular Interventions | |
| dc.title | P2Y12 Inhibitor Monotherapy Combined With Colchicine Following PCI in ACS Patients: The MACT Pilot Study | en |
| dc.contributor.institution | Department of Clinical, Pharmaceutical and Biological Science | |
| dc.contributor.institution | Basic and Clinical Science Unit | |
| dc.contributor.institution | Centre for Health Services and Clinical Research | |
| dc.contributor.institution | School of Life and Medical Sciences | |
| dc.description.status | Peer reviewed | |
| dc.date.embargoedUntil | 2024-08-14 | |
| rioxxterms.versionofrecord | 10.1016/j.jcin.2023.05.035 | |
| rioxxterms.type | Journal Article/Review | |
| herts.preservation.rarelyaccessed | true | |
