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Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

dc.contributor.authorKanji, Rahim
dc.contributor.authorGue, Ying X.
dc.contributor.authorFarag, Mohamed F.
dc.contributor.authorSpencer, Neil H.
dc.contributor.authorMutch, Nicola J.
dc.contributor.authorGorog, Diana A.
dc.date.accessioned2023-10-11T14:00:00Z
dc.date.available2023-10-11T14:00:00Z
dc.date.issued2022-11-14
dc.identifier.citationKanji , R , Gue , Y X , Farag , M F , Spencer , N H , Mutch , N J & Gorog , D A 2022 , ' Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction ' , JACC: Basic to Translational Science , vol. 7 , no. 11 , pp. 1069-1082 . https://doi.org/10.1016/j.jacbts.2022.05.007
dc.identifier.issn2452-302X
dc.identifier.otherJisc: 562868
dc.identifier.otherJisc: 562868
dc.identifier.otherJisc: 731251
dc.identifier.urihttp://hdl.handle.net/2299/26895
dc.description© 2022 The Author(s). Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.abstractHypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.en
dc.format.extent14
dc.format.extent1197737
dc.language.isoeng
dc.relation.ispartofJACC: Basic to Translational Science
dc.subjectfibrinolysis
dc.subjectmyocardial infarction
dc.subjectplatelet function
dc.subjectthrombosis
dc.subjectCardiology and Cardiovascular Medicine
dc.titleDeterminants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarctionen
dc.contributor.institutionManaging Complex Change Research Group
dc.contributor.institutionHertfordshire Business School
dc.contributor.institutionStatistical Services Consulting Unit
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Astrophysics Research (CAR)
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85141777397&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1016/j.jacbts.2022.05.007
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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