Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation

Abstract

We read the paper by Clavería and co-workers with interest.1We strongly believe that the conclusions of their paper, suggesting that occlusion (occlusion time (OT)) in the global thrombosis test (GTT) is due to coagulation, rather than shear-induced platelet thrombus formation, is wrong and the evidence and arguments they present are fundamentally flawed. The authors have made major errors both in the approach to their experiments and in their interpretations of their results. The evidence which they demonstrate, shows that occlusion in the GTT is, in fact, caused by high shear-induced platelet thrombus formation, the complete opposite to their interpretation of their results. We set out below the evidence for that.