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dc.contributor.authorSalarkia, Ehsan
dc.contributor.authorMehdipoor, Mahdis
dc.contributor.authorMolaakbari, Elahe
dc.contributor.authorKhosravi, Ahmad
dc.contributor.authorSazegar, Mohammad Reza
dc.contributor.authorSalari, Zohreh
dc.contributor.authorRad, Iman
dc.contributor.authorDabiri, Shahriar
dc.contributor.authorJoukar, Siyavash
dc.contributor.authorSharifi, Iraj
dc.contributor.authorRen, Guogang
dc.date.accessioned2023-12-07T14:15:01Z
dc.date.available2023-12-07T14:15:01Z
dc.date.issued2023-10-25
dc.identifier.citationSalarkia , E , Mehdipoor , M , Molaakbari , E , Khosravi , A , Sazegar , M R , Salari , Z , Rad , I , Dabiri , S , Joukar , S , Sharifi , I & Ren , G 2023 , ' Exploring mesoporous silica nanoparticles as oral insulin carriers: In-silico and in vivo evaluation ' , Heliyon , vol. 9 , no. 10 , e20430 , pp. 1-14 . https://doi.org/10.1016/j.heliyon.2023.e20430
dc.identifier.issn2405-8440
dc.identifier.otherPubMedCentral: PMC10556789
dc.identifier.otherORCID: /0000-0001-8865-1526/work/148368031
dc.identifier.urihttp://hdl.handle.net/2299/27262
dc.description© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.abstractThe advancements in nanoscience have brought attention to the potential of utilizing nanoparticles as carriers for oral insulin administration. This study aims to investigate the effectiveness of synthesized polymeric mesoporous silica nanoparticles (MSN) as carriers for oral insulin and their interactions with insulin and IR through in-silico docking. Diabetic rats were treated with various MSN samples, including pure MSN, Amin-grafted MSN/PEG/Insulin (AMPI), Al-grafted MSN/PEG/Insulin (AlMPI), Zinc-grafted MSN/PEG/Insulin (ZNPI), and Co-grafted MSN/PEG/Insulin (CMPI). The nanocomposites were synthesized using a hybrid organic-inorganic method involving MSNs, graphene oxide, and insulin. Characterization of the nanocomposites was conducted using X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM). In vivo tests included the examination of blood glucose levels and histopathological parameters of the liver and pancreas in type 1 diabetic rats. The MSN family demonstrated a significant reduction in blood glucose levels compared to the diabetic control group (p < 0.001). The synthesized nanocomposites exhibited safety, non-toxicity, fast operation, self-repairing pancreas, cost-effectiveness, and high efficiency in the oral insulin delivery system. In the in-silico study, Zn-grafted MSN, Co-grafted MSN, and Al-grafted MSN were selected. Docking results revealed strong interactions between MSN compounds and insulin and IR, characterized by the formation of hydrogen bonds and high binding energy. Notably, Co-grafted MSN showed the highest docking scores of -308.171 kcal/mol and -337.608 kcal/mol to insulin and IR, respectively. These findings demonstrate the potential of polymeric MSN as effective carriers for oral insulin, offering promising prospects for diabetes treatment.en
dc.format.extent14
dc.format.extent8986733
dc.language.isoeng
dc.relation.ispartofHeliyon
dc.subjectDiabetic rat
dc.subjectIn-silico
dc.subjectMesoporous silica nanoparticles
dc.subjectOral insulin
dc.subjectPEG
dc.subjectGeneral
dc.titleExploring mesoporous silica nanoparticles as oral insulin carriers: In-silico and in vivo evaluationen
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionDepartment of Engineering and Technology
dc.contributor.institutionSchool of Physics, Engineering & Computer Science
dc.contributor.institutionBioEngineering
dc.contributor.institutionMaterials and Structures
dc.contributor.institutionCentre for Engineering Research
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85172805704&partnerID=8YFLogxK
rioxxterms.versionofrecord10.1016/j.heliyon.2023.e20430
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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