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dc.contributor.authorCirino, G.
dc.contributor.authorCicala, C.
dc.contributor.authorMancuso, F.
dc.contributor.authorBaydoun, A. R.
dc.contributor.authorWallace, J. L.
dc.date.accessioned2009-01-28T11:37:18Z
dc.date.available2009-01-28T11:37:18Z
dc.date.issued1995
dc.identifier.citationCirino , G , Cicala , C , Mancuso , F , Baydoun , A R & Wallace , J L 1995 , ' Flurbinitroxybutylester : a novel anti-inflammatory drug has enhanced antithrombotic activity ' , Thrombosis Research , vol. 79 , pp. 73-81 . https://doi.org/10.1016/0049-3848(95)00092-6
dc.identifier.issn0049-3848
dc.identifier.otherPURE: 122851
dc.identifier.otherPURE UUID: 9c34e1c7-d413-4090-96c9-de6c976d0bd1
dc.identifier.otherdspace: 2299/2853
dc.identifier.otherScopus: 0029015241
dc.identifier.urihttp://hdl.handle.net/2299/2853
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/00493848 Copyright Elsevier Ireland Ltd. DOI: 10.1016/0049-3848(95)00092-6 [Full text of this article is not available in the UHRA]
dc.description.abstractWe have recently shown that the introduction of a nitroxybutylester moiety into flurbiprofen, to form Flurbi-NO, results in a compound with markedly reduced undesired effects in the gastrointestinal tract. This effect has been shown to be linked to nitric oxide release from the Flurbi-NO. Here we have investigated whether this is associated with a reduction in platelet aggregability in vivo, as assessed in a mouse model of thromboembolism and a rat model of platelet aggregation, and found in both models that Flurbi-NO is more potent than flurbiprofen at inhibiting collagen-induced platelet aggregation. Further in vitro studies using human washed platelets and cells in culture suggest that this is due to the release of NO from Flurbi-NO following the action of (possibly plasma) esterases. Together with our earlier data, these results strongly suggest that Flurbi-NO and other members of this class of drugs, have particular potential as antithrombotic agents devoid of gastrointestinal side effects.en
dc.language.isoeng
dc.relation.ispartofThrombosis Research
dc.titleFlurbinitroxybutylester : a novel anti-inflammatory drug has enhanced antithrombotic activityen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/0049-3848(95)00092-6
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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