dc.contributor.author | Cirino, G. | |
dc.contributor.author | Cicala, C. | |
dc.contributor.author | Mancuso, F. | |
dc.contributor.author | Baydoun, A. R. | |
dc.contributor.author | Wallace, J. L. | |
dc.date.accessioned | 2009-01-28T11:37:18Z | |
dc.date.available | 2009-01-28T11:37:18Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | Cirino , G , Cicala , C , Mancuso , F , Baydoun , A R & Wallace , J L 1995 , ' Flurbinitroxybutylester : a novel anti-inflammatory drug has enhanced antithrombotic activity ' , Thrombosis Research , vol. 79 , pp. 73-81 . https://doi.org/10.1016/0049-3848(95)00092-6 | |
dc.identifier.issn | 0049-3848 | |
dc.identifier.other | PURE: 122851 | |
dc.identifier.other | PURE UUID: 9c34e1c7-d413-4090-96c9-de6c976d0bd1 | |
dc.identifier.other | dspace: 2299/2853 | |
dc.identifier.other | Scopus: 0029015241 | |
dc.identifier.uri | http://hdl.handle.net/2299/2853 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/00493848 Copyright Elsevier Ireland Ltd. DOI: 10.1016/0049-3848(95)00092-6 [Full text of this article is not available in the UHRA] | |
dc.description.abstract | We have recently shown that the introduction of a nitroxybutylester moiety into flurbiprofen, to form Flurbi-NO, results in a compound with markedly reduced undesired effects in the gastrointestinal tract. This effect has been shown to be linked to nitric oxide release from the Flurbi-NO. Here we have investigated whether this is associated with a reduction in platelet aggregability in vivo, as assessed in a mouse model of thromboembolism and a rat model of platelet aggregation, and found in both models that Flurbi-NO is more potent than flurbiprofen at inhibiting collagen-induced platelet aggregation. Further in vitro studies using human washed platelets and cells in culture suggest that this is due to the release of NO from Flurbi-NO following the action of (possibly plasma) esterases. Together with our earlier data, these results strongly suggest that Flurbi-NO and other members of this class of drugs, have particular potential as antithrombotic agents devoid of gastrointestinal side effects. | en |
dc.language.iso | eng | |
dc.relation.ispartof | Thrombosis Research | |
dc.title | Flurbinitroxybutylester : a novel anti-inflammatory drug has enhanced antithrombotic activity | en |
dc.contributor.institution | Department of Human and Environmental Sciences | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1016/0049-3848(95)00092-6 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |