Show simple item record

dc.contributor.authorBaydoun, A. R.
dc.contributor.authorMarkham, A.
dc.contributor.authorMorgan, R.M.
dc.contributor.authorSweetman, A.J.
dc.identifier.citationBaydoun , A R , Markham , A , Morgan , R M & Sweetman , A J 1988 , ' Palmitoyl carnitine : an endogenous promoter of calcium efflux from rat heart mitochondria ' , Biochemical Pharmacology , vol. 37 , no. 16 , pp. 3103-3107 .
dc.identifier.otherPURE: 184458
dc.identifier.otherPURE UUID: 35d4b36c-d250-45dc-a51a-58bf5e968b60
dc.identifier.otherdspace: 2299/2862
dc.identifier.otherScopus: 0023693854
dc.descriptionOriginal article can be found at: Copyright Elsevier Inc. DOI: 10.1016/0006-2952(88)90307-3 [Full text of this article is not available in the UHRA]
dc.description.abstractThe effects of the fatty acid ester palmitoyl carnitine (PC) on mitochondrial Ca2+ handling and ATP synthesis are described. At low concentrations (5–40 μM) PC was found to produce changes in mitochondrial Ca2+ handling, the most significant effect (P < 0.05) being the promotion of Ca2+ efflux (EC25 = 1.19 ± 0.11 μM). Studies on mitochondrial substrate oxidation in the presence of either glutamate plus malate, or succinate, confirmed the ability of PC (10–100 μM) to cause loss of respiratory control as shown by reductions in the Respiratory Control Index for each substrate. It was concluded that the effect of PC on Ca2+ transport was due to a direct action on the Na+---Ca2+ antiporter system, whilst the effect on respiration was due to an uncoupling action.en
dc.relation.ispartofBiochemical Pharmacology
dc.titlePalmitoyl carnitine : an endogenous promoter of calcium efflux from rat heart mitochondriaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record