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High Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agents

dc.contributor.authorTietze, Lysann
dc.contributor.authorUrbano, Laura
dc.contributor.authorEisenmann, Stephan
dc.contributor.authorSchwarzinger, Jacqueline
dc.contributor.authorKollan, Julia
dc.contributor.authorForbes, Ben
dc.contributor.authorDailey, Lea Ann
dc.contributor.authorHädrich, Gabriela
dc.date.accessioned2025-01-21T11:15:02Z
dc.date.available2025-01-21T11:15:02Z
dc.date.issued2025-01-07
dc.identifier.citationTietze , L , Urbano , L , Eisenmann , S , Schwarzinger , J , Kollan , J , Forbes , B , Dailey , L A & Hädrich , G 2025 , ' High Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agents ' , Pharmaceutical Research . https://doi.org/10.1007/s11095-024-03806-y
dc.identifier.issn1573-904X
dc.identifier.otherRIS: urn:606E652096595BC2D1AFAAC03097136A
dc.identifier.otherRIS: Tietze2025
dc.identifier.urihttp://hdl.handle.net/2299/28730
dc.description© 2025, The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/
dc.description.abstractIn vitro screening of macrophages for drug-induced effects, such as phospholipidosis, is useful for detecting potentially problematic compounds in the preclinical development of oral inhaled products. High-content image analysis (HCIA) is a multi-parameter approach for cytotoxicity screening. This study provides new insights into HCIA-derived response patterns of murine J774A.1 cells and primary human alveolar macrophages (hAM).en
dc.format.extent16
dc.format.extent6022590
dc.language.isoeng
dc.relation.ispartofPharmaceutical Research
dc.titleHigh Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agentsen
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionCentre for Future Societies Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1007/s11095-024-03806-y
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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