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dc.contributor.authorAkomeah, F
dc.contributor.authorNazir, T
dc.contributor.authorMartin, G P
dc.contributor.authorBrown, Marc
dc.date.accessioned2009-03-10T09:45:29Z
dc.date.available2009-03-10T09:45:29Z
dc.date.issued2004-02
dc.identifier.citationAkomeah , F , Nazir , T , Martin , G P & Brown , M 2004 , ' Effect of heat on the percutaneous absorption and skin retention of three model penetrants ' , European Journal of Pharmaceutical Sciences , vol. 21 , no. 2-3 , pp. 337-345 . https://doi.org/10.1016/j.ejps.2003.10.025
dc.identifier.issn0928-0987
dc.identifier.otherPURE: 184579
dc.identifier.otherPURE UUID: 5af2e4ef-e663-403e-ab14-23c783d9e15f
dc.identifier.otherdspace: 2299/3009
dc.identifier.otherWOS: 000189093300026
dc.identifier.otherScopus: 0742269694
dc.identifier.urihttp://hdl.handle.net/2299/3009
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/09280987 Copyright Elsevier B.V. DOI: 10.1016/j.ejps.2003.10.025 [Full text of this article is not available in the UHRA]
dc.description.abstractThe effect of heat on the transdermal delivery of model penetrants of differing lipophilicity through artificial membranes (non-rate limiting) and human epidermis was investigated in vitro. Saturated suspensions of the model penetrants; methyl paraben (MP), butyl paraben (BP) and caffeine (CF) in deionised water (vehicle) were used to attain maximal thermodynamic activity. Franz cell experiments were performed at temperatures ranging from 23 to 45 degreesC using the infinite dose method. Artificial membrane studies showed the penetrant diffusivity (diffusion coefficient) in the vehicle to be totally dependent on temperature and not changes in donor solubility. Epidermal flux and retention of all penetrants was found to be affected by temperature. The amount of penetrant retained in the epidermis was found to be in the order BP > CF > MP whilst the transdermal fluxes increased in the order MP > BP > CF with increasing receptor temperature. Estimated epidermal diffusivity of MP was found to be significantly affected by temperature (P less than or equal to 0.05) compared to BP and CF. Using Arrhenius plots, a lower activation energy was recorded for CF and may suggest a difference in permeation kinetics compared to the other penetrants. (C) 2003 Elsevier B.V. All rights reserved.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.subjectheat
dc.subjecttransdermal
dc.subjectactivation energy
dc.subjectskin temperature
dc.subjectFranz cell
dc.subjectHUMAN STRATUM-CORNEUM
dc.subjectTHERMAL-ANALYSIS
dc.subjectUV FILTERS
dc.subjectRAT SKIN
dc.subjectPERMEABILITY
dc.subjectTEMPERATURE
dc.subjectPERMEATION
dc.subjectDRUGS
dc.subjectENHANCERS
dc.subjectDELIVERY
dc.titleEffect of heat on the percutaneous absorption and skin retention of three model penetrantsen
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
dcterms.dateAccepted2004-02
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejps.2003.10.025
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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