Show simple item record

dc.contributor.authorRoberts, G.W.
dc.contributor.authorDone, D.J.
dc.contributor.authorBruton, C.
dc.contributor.authorCrow, T.J.
dc.date.accessioned2009-04-02T14:01:40Z
dc.date.available2009-04-02T14:01:40Z
dc.date.issued1990
dc.identifier.citationRoberts , G W , Done , D J , Bruton , C & Crow , T J 1990 , ' A “Mock up” of schizophrenia : Temporal lobe epilepsy and schizophrenia-like psychosis ' , Biological Psychiatry , vol. 28 , no. 2 , pp. 127-143 . https://doi.org/10.1016/0006-3223(90)90630-K
dc.identifier.issn0006-3223
dc.identifier.otherPURE: 190243
dc.identifier.otherPURE UUID: ac14c417-034a-40c3-babc-45ef08fc92f7
dc.identifier.otherdspace: 2299/3111
dc.identifier.otherScopus: 0025323015
dc.identifier.urihttp://hdl.handle.net/2299/3111
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/00063223 Copyright Society of Biological Psychiatry. DOI: 10.1016/0006-3223(90)90630-K [Full text of this article is not available in the UHRA]
dc.description.abstractSchizoprenia-like psychoses occur more frequently than expected in patients with chronic temporal lobe epilepsy. We have analyzed pathological and clinical data from a series (n = 249) of temporal lobectomies to determine the factors that may relate to the development of schizophrenia-like psychosis. Schizophrenia-like psychoses did not occur at random; they were significantly associated with lesions that (1) originated in the fetus or perinatally, (2) affected neurons in the medial temporal lobe, and (3) gae an early age of first fit. Gangliogliomas—developmental lesions of the medial temporal lobe containing aberrant neurons—were disproportionately (p < 0.001) associated with risk of psychosis. Schizophrenia-like psychoses arising preoperatively occurred more often (p = 0.1) with left-sided lesions. Asymmetry of lesion was not present in cases with postoperative psychoses. These findings are of interest in relation to recent studies suggesting that the structural abnormalities found in the brains of schizophrenic arise during fetal brain development.en
dc.language.isoeng
dc.relation.ispartofBiological Psychiatry
dc.titleA “Mock up” of schizophrenia : Temporal lobe epilepsy and schizophrenia-like psychosisen
dc.contributor.institutionDepartment of Psychology
dc.description.statusPeer reviewed
rioxxterms.versionofrecordhttps://doi.org/10.1016/0006-3223(90)90630-K
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record