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dc.contributor.authorCrow, T.J.
dc.contributor.authorDone, D.J.
dc.date.accessioned2009-04-03T12:16:16Z
dc.date.available2009-04-03T12:16:16Z
dc.date.issued1986
dc.identifier.citationCrow , T J & Done , D J 1986 , ' Age of onset of schizophrenia in siblings: A test of the contagion hypothesis ' Psychiatry Research , vol. 18 , no. 2 , pp. 107-117 . https://doi.org/10.1016/0165-1781(86)90023-5
dc.identifier.issn0165-1781
dc.identifier.otherPURE: 196207
dc.identifier.otherPURE UUID: 24daea02-83ad-4727-a81a-3713d096fc4d
dc.identifier.otherdspace: 2299/3126
dc.identifier.otherScopus: 0022454081
dc.identifier.urihttp://hdl.handle.net/2299/3126
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/01651781 Copyright Elsevier Ltd. DOI: 10.1016/0165-1781(86)90023-5 [Full text of this article is not available in the UHRA]
dc.description.abstractThe possibility that schizophrenia is horizontally transmitted has been assessed in an analysis of age of onset in 264 recorded pairs of siblings with the disease. Age of onset was found to be correlated between siblings, and there was a tendency for the disease to occur at an earlier age in the younger sibling. Three explanations for this finding are considered: horizontal transmission, early detection, and ascertainment bias. An analysis by date of birth differences between siblings gives results consistent with horizontal transmission, but analysis by order of onset of illness (which shows that the age shift is not seen in elder-sibling-ill-first pairs) indicates that ascertainment bias (which arises from a tendency to include an excess of early onsets in younger siblings) is a more cogent explanation of the age shift. Although horizontal transmission is not altogether eliminated, the data suggest that age of onset is determined by genetic or prenatal factors rather than environmental precipitants in postnatal life. The retrovirus/transposon hypothesis (Crow, 1984) can accommodate the findings more readily than the gene-virus interaction hypothesis (Crow, 1983).en
dc.language.isoeng
dc.relation.ispartofPsychiatry Research
dc.titleAge of onset of schizophrenia in siblings: A test of the contagion hypothesisen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionPsychology
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.contributor.institutionHealth Services and Medicine
dc.contributor.institutionHealth and Clinical Psychology group
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/0165-1781(86)90023-5
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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