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dc.contributor.authorGoh, V.
dc.contributor.authorHalligan, S.
dc.contributor.authorWellsted, D.
dc.contributor.authorBartram, C.I.
dc.identifier.citationGoh , V , Halligan , S , Wellsted , D & Bartram , C I 2009 , ' Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study ' , European Radiology , vol. 19 , no. 1 , pp. 79-89 .
dc.identifier.otherPURE: 119071
dc.identifier.otherPURE UUID: 6e602af7-df99-4f4e-9cfe-62a20b89bf0c
dc.identifier.otherdspace: 2299/3452
dc.identifier.otherScopus: 59249106620
dc.description“The original publication is available at”. Copyright Springer. [Full text of this article is not available in the UHRA]
dc.description.abstractWe aimed to determine whether perfusion CT measurements at colorectal cancer staging may predict for subsequent metastatic relapse. Fifty two prospective patients underwent perfusion CT at staging to estimate tumour blood flow, blood volume, mean transit time, and permeability surface area product. Patients considered metastasis free and suitable for surgery underwent curative resection subsequently. At final analysis, a median of 48.6 months post-surgery, patients were divided into those who remained disease free, and those with subsequent metastases. Vascular parameters for these two groups were compared using t-testing, and receiver operator curve analysis was performed to determine the sensitivity and specificity of these vascular parameters for predicting metastases. Thirty seven (71%) patients underwent curative surgery; data were available for 35: 26 (74%) remained disease free; 9 (26%) recurred (8 metastatic, 1 local). Tumour blood flow differed significantly between disease-free and metastatic patients (76.0 versus 45.7 ml/min/100 g tissue; p = 0.008). With blood flow <64 ml/min/100 g tissue, sensitivity and specificity (95% CI) for development of metastases were 100% (60–100%) and 73% (53–87%), respectively. Our preliminary findings suggest that primary tumour blood flow might potentially be a useful predictor warranting further study.en
dc.relation.ispartofEuropean Radiology
dc.titleCan perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot studyen
dc.contributor.institutionDepartment of Allied Health Professions and Midwifery
dc.contributor.institutionCentre for Lifespan and Chronic Illness Research
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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