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dc.contributor.authorLearoyd, Tristan
dc.contributor.authorBurrows, J.L.
dc.contributor.authorFrench, E.
dc.contributor.authorSeville, P.C.
dc.identifier.citationLearoyd , T , Burrows , J L , French , E & Seville , P C 2009 , ' Sustained delivery by leucine-modified chitosan spray-dried respirable powders ' , International Journal of Pharmaceutics , vol. 372 , no. 1-2 , pp. 97-104 .
dc.identifier.otherPURE: 184950
dc.identifier.otherPURE UUID: bf30ce91-5601-44d4-adc2-724d43815b32
dc.identifier.otherdspace: 2299/3453
dc.identifier.otherScopus: 64149102365
dc.descriptionOriginal article can be found at: Copyright Elsevier B.V. DOI: 10.1016/j.ijpharm.2009.01.017 [Full text of this article is not available in the UHRA]
dc.description.abstractThe controlled co-delivery of multiple agents to the lung offers potential benefits to patients. This study investigated the preparation and characterisation of highly respirable spray-dried powders displaying the sustained release of two chemically distinct therapeutic agents. Spray-dried powders were produced from 30% (v/v) aqueous ethanol formulations that contained hydrophilic (terbutaline sulphate) and hydrophobic (beclometasone dipropionate) model drugs, chitosan (as a drug release modifier) and leucine (aerosolisation enhancer). The influence of chitosan molecular weight on spray-drying thermal efficiency, aerosol performance and drug release profile was investigated. Resultant powders were physically characterised: with in vitro aerosolisation performance and drug release profile investigated by the Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. It was found that increased chitosan molecular weight gave increased spray-drying thermal efficiency. The powders generated were of a suitable size for inhalation—with emitted doses over 90% and fine particle fractions up to 72% of the loaded dose. Sustained drug release profiles were observed in dissolution tests for both agents: increased chitosan molecular weight associated with increased duration of drug release. The controlled co-delivery of hydrophilic and hydrophobic entities underlines the capability of spray drying to produce respirable particles with sustained release for delivery to the lung.en
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.titleSustained delivery by leucine-modified chitosan spray-dried respirable powdersen
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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