dc.contributor.author | Learoyd, Tristan | |
dc.contributor.author | Burrows, J.L. | |
dc.contributor.author | French, E. | |
dc.contributor.author | Seville, P.C. | |
dc.date.accessioned | 2009-06-01T12:24:00Z | |
dc.date.available | 2009-06-01T12:24:00Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Learoyd , T , Burrows , J L , French , E & Seville , P C 2009 , ' Sustained delivery by leucine-modified chitosan spray-dried respirable powders ' , International Journal of Pharmaceutics , vol. 372 , no. 1-2 , pp. 97-104 . https://doi.org/10.1016/j.ijpharm.2009.01.017 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.other | dspace: 2299/3453 | |
dc.identifier.uri | http://hdl.handle.net/2299/3453 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/03785173 Copyright Elsevier B.V. DOI: 10.1016/j.ijpharm.2009.01.017 [Full text of this article is not available in the UHRA] | |
dc.description.abstract | The controlled co-delivery of multiple agents to the lung offers potential benefits to patients. This study investigated the preparation and characterisation of highly respirable spray-dried powders displaying the sustained release of two chemically distinct therapeutic agents. Spray-dried powders were produced from 30% (v/v) aqueous ethanol formulations that contained hydrophilic (terbutaline sulphate) and hydrophobic (beclometasone dipropionate) model drugs, chitosan (as a drug release modifier) and leucine (aerosolisation enhancer). The influence of chitosan molecular weight on spray-drying thermal efficiency, aerosol performance and drug release profile was investigated. Resultant powders were physically characterised: with in vitro aerosolisation performance and drug release profile investigated by the Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. It was found that increased chitosan molecular weight gave increased spray-drying thermal efficiency. The powders generated were of a suitable size for inhalation—with emitted doses over 90% and fine particle fractions up to 72% of the loaded dose. Sustained drug release profiles were observed in dissolution tests for both agents: increased chitosan molecular weight associated with increased duration of drug release. The controlled co-delivery of hydrophilic and hydrophobic entities underlines the capability of spray drying to produce respirable particles with sustained release for delivery to the lung. | en |
dc.language.iso | eng | |
dc.relation.ispartof | International Journal of Pharmaceutics | |
dc.title | Sustained delivery by leucine-modified chitosan spray-dried respirable powders | en |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.ijpharm.2009.01.017 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |