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        Patch and whole cell voltage-clamp of single mammalian visceral and vascular smooth muscle cells

        Author
        Bolton, T.B.
        Lang, R.J.
        Takewaki, T.
        Benham, C.D.
        Attention
        2299/3485
        Abstract
        Dispersal of the constituent cells of mammalian visceral and vascular smooth muscles has permitted recordings both of membrane currents under whole-cell voltage clamp, and of currents through single ionic channels using the patch-clamp technique. A rectangular depolarizing step applied to a single cell under voltage clamp yielded a net inward current followed by a net outward current in normal physiological solution. In isolated, inside-out patches of cell membrane a calcium- and potential-sensitive K channel (100 pS conductance) and a calcium-insensitive, potential-sensitive K+ channel (50 pS conductance) with slow kinetics have so far been identified and characterized.
        Publication date
        1985
        Published in
        Cellular and Molecular Life Sciences
        Published version
        https://doi.org/10.1007/BF01970006
        Other links
        http://hdl.handle.net/2299/3485
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