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dc.contributor.authorBenham, C.D.
dc.contributor.authorBrown, T.H.
dc.contributor.authorCooper, D.C.
dc.contributor.authorEvans, M.L.
dc.contributor.authorHarries, M.
dc.contributor.authorHerdon, H.J.
dc.contributor.authorMeakin, J.E.
dc.contributor.authorMurkitt, K.L.
dc.contributor.authorPatel, S.
dc.contributor.authorRoberts, J.C.
dc.contributor.authorRothaul, A.L.
dc.contributor.authorSmith, S.J.
dc.contributor.authorWood, N.
dc.contributor.authorHunter, A.J.
dc.identifier.citationBenham , C D , Brown , T H , Cooper , D C , Evans , M L , Harries , M , Herdon , H J , Meakin , J E , Murkitt , K L , Patel , S , Roberts , J C , Rothaul , A L , Smith , S J , Wood , N & Hunter , A J 1993 , ' SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia ' , Neuropharmacology , vol. 32 , pp. 1249-1257 .
dc.identifier.otherPURE: 128739
dc.identifier.otherPURE UUID: ed5e505d-dc8b-4a91-98d9-9592caf10f1e
dc.identifier.otherdspace: 2299/3494
dc.identifier.otherScopus: 0027426436
dc.descriptionOriginal article can be found at: Copyright Elsevier Ltd. DOI: 10.1016/0028-3908(93)90019-Y [Full text of this article is not available in the UHRA]
dc.description.abstractWe have characterised the Ca2+ channel blocking properties of a new non-peptide Ca2+ channel antagonist, SB 201823-A, in cultures of rat sensory neurones. The IC50 for SB 201823-A against total Ca2+ current in sensory neurones was 4.9 μM. SB 201823-A showed little selectivity for sub-types of neuronal Ca2+ channel but was selective for Ca2+ channels over Na+ and K+ channels. Efficacy against other types of cation channel such as agonist gated channels was not assessed. SB 201823-A was neuroprotective in vivo when administered post-ischaemia in one focal and one global model of neuronal ischaemia. In the rat photothrombotic focal lesion model, SB 201823-A administered i.p. 10 min post-ischaemia resulted in a dramatic reduction in lesion volume. In the gerbil bilateral carotid artery occlusion global model, SB 201823-A dosed i.p. 30 min post-occlusion resulted in both histological and functional improvements when compared to vehicle treated animals. These data suggest that such novel neuronal Ca2+ channel antagonists may have potential in ameliorating both the pathological and functional consequences of stroke in man.en
dc.titleSB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemiaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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