Show simple item record

dc.contributor.authorBenham, C.D.
dc.contributor.authorBrown, T.H.
dc.contributor.authorCooper, D.C.
dc.contributor.authorEvans, M.L.
dc.contributor.authorHarries, M.
dc.contributor.authorHerdon, H.J.
dc.contributor.authorMeakin, J.E.
dc.contributor.authorMurkitt, K.L.
dc.contributor.authorPatel, S.
dc.contributor.authorRoberts, J.C.
dc.contributor.authorRothaul, A.L.
dc.contributor.authorSmith, S.J.
dc.contributor.authorWood, N.
dc.contributor.authorHunter, A.J.
dc.date.accessioned2009-06-04T08:14:09Z
dc.date.available2009-06-04T08:14:09Z
dc.date.issued1993
dc.identifier.citationBenham , C D , Brown , T H , Cooper , D C , Evans , M L , Harries , M , Herdon , H J , Meakin , J E , Murkitt , K L , Patel , S , Roberts , J C , Rothaul , A L , Smith , S J , Wood , N & Hunter , A J 1993 , ' SB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemia ' , Neuropharmacology , vol. 32 , pp. 1249-1257 . https://doi.org/10.1016/0028-3908(93)90019-Y
dc.identifier.issn0028-3908
dc.identifier.otherPURE: 128739
dc.identifier.otherPURE UUID: ed5e505d-dc8b-4a91-98d9-9592caf10f1e
dc.identifier.otherdspace: 2299/3494
dc.identifier.otherScopus: 0027426436
dc.identifier.urihttp://hdl.handle.net/2299/3494
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/00283908 Copyright Elsevier Ltd. DOI: 10.1016/0028-3908(93)90019-Y [Full text of this article is not available in the UHRA]
dc.description.abstractWe have characterised the Ca2+ channel blocking properties of a new non-peptide Ca2+ channel antagonist, SB 201823-A, in cultures of rat sensory neurones. The IC50 for SB 201823-A against total Ca2+ current in sensory neurones was 4.9 μM. SB 201823-A showed little selectivity for sub-types of neuronal Ca2+ channel but was selective for Ca2+ channels over Na+ and K+ channels. Efficacy against other types of cation channel such as agonist gated channels was not assessed. SB 201823-A was neuroprotective in vivo when administered post-ischaemia in one focal and one global model of neuronal ischaemia. In the rat photothrombotic focal lesion model, SB 201823-A administered i.p. 10 min post-ischaemia resulted in a dramatic reduction in lesion volume. In the gerbil bilateral carotid artery occlusion global model, SB 201823-A dosed i.p. 30 min post-occlusion resulted in both histological and functional improvements when compared to vehicle treated animals. These data suggest that such novel neuronal Ca2+ channel antagonists may have potential in ameliorating both the pathological and functional consequences of stroke in man.en
dc.language.isoeng
dc.relation.ispartofNeuropharmacology
dc.titleSB 201823-A, A neuronal Ca antagonist is neuroprotective in two models of cerebral ischaemiaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dcterms.dateAccepted1993
rioxxterms.versionofrecordhttps://doi.org/10.1016/0028-3908(93)90019-Y
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record