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dc.contributor.authorMeadows, H.J.
dc.contributor.authorHarries, M.
dc.contributor.authorThompson, M.
dc.contributor.authorBenham, C.D.
dc.identifier.citationMeadows , H J , Harries , M , Thompson , M & Benham , C D 1997 , ' SB 205384 slows the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum ' , British Journal of Pharmacology , vol. 121 , no. 7 , pp. 1334-1338 .
dc.identifier.otherPURE: 184983
dc.identifier.otherPURE UUID: 47be58e9-5c52-48c9-8422-49b21b8d03d6
dc.identifier.otherdspace: 2299/3495
dc.identifier.otherScopus: 0030610069
dc.descriptionOriginal article can be found at: Copyright Nature Publishing Group and British Pharmacological Society. DOI: 10.1038/sj.bjp.0701251 [Full text of this article is not available in the UHRA]
dc.description.abstract4-Amino-7-hydroxy-2-methyl-5,6,7,8,-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid, but-2-ynyl ester (SB-205384) and other γ-aminobutyric acidA (GABAA) receptor modulators were tested for their effects on GABA-activated chloride currents in rat cerebellar granule cells by use of the whole-cell patch clamp technique. The major effect of SB-205384 on GABAA-activated current was an increase in the half-life of decay of the response once the agonist had been removed. This is in contrast to many GABAA receptor modulators that have previously been shown to potentiate GABA-activated currents. This profile could be explained if SB-205384 stabilizes the channel in open and desensitized states so that channel closing is dramatically slowed. Such a modulatory profile may produce a novel behavioural profile in vivo.en
dc.relation.ispartofBritish Journal of Pharmacology
dc.titleSB 205384 slows the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellumen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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