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dc.contributor.authorRead, S.J.
dc.contributor.authorSmith, M.I.
dc.contributor.authorBenham, C.D.
dc.contributor.authorHunter, A.J.
dc.contributor.authorParsons, A.A.
dc.date.accessioned2009-06-04T08:29:42Z
dc.date.available2009-06-04T08:29:42Z
dc.date.issued1997
dc.identifier.citationRead , S J , Smith , M I , Benham , C D , Hunter , A J & Parsons , A A 1997 , ' Furosemide inhibits regenerative cortical spreading depression in anaesthetised cats ' , Cephalalgia , vol. 17 , no. 8 , pp. 826-832 . https://doi.org/10.1046/j.1468-2982.1997.1708826.x
dc.identifier.issn0333-1024
dc.identifier.otherPURE: 124175
dc.identifier.otherPURE UUID: fd14c630-3a44-415f-81ae-a137b004b71f
dc.identifier.otherdspace: 2299/3496
dc.identifier.otherScopus: 0031467679
dc.identifier.urihttp://hdl.handle.net/2299/3496
dc.description‘The definitive version is available at www.blackwell-synergy.com '. Copyright Blackwell Publishing. DOI: 10.1046/j.1468-2982.1997.1708826.x [Full text of this article is not available in the UHRA]
dc.description.abstractIonic perturbations occur during cortical spreading depression (SD), a phenomenon implicated in migraine pathophysiology. We studied the effect of 0.2,2 and 20 mg kg-1 iv (n=4) furosemide on cortical direct current (d.c.) potential, cerebrovascular laser Doppler flux (rCBFLDF), artery diameter and NO concentration in the parietal cortex of the anaesthetized cat during repetitive SD. In vehicle treated animals (n=4), SD activity was sustained for 50 1.8 min. However, duration of SD activity was significantly reduced when compared to vehicle to 39 6.6 (n=4), 3.1 8.3 (n = 4) and 27.3 11.3 min (n=4), at 0.2, 2 and 20 mg kg-1 iv furosemide respectively. It is hypothesized that the mechanism of inhibition of SD d.c. activity by furosemide may be through alterations in cortica ion buffering capacity or inhibition of cell swelling in neurones or glia. These mechanisms may represent potential novel drug targets in future migraine therapy.en
dc.language.isoeng
dc.relation.ispartofCephalalgia
dc.titleFurosemide inhibits regenerative cortical spreading depression in anaesthetised catsen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.description.statusPeer reviewed
dcterms.dateAccepted1997
rioxxterms.versionofrecordhttps://doi.org/10.1046/j.1468-2982.1997.1708826.x
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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