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        Lack of effect of the novel anticonvulsant SB 204269 on voltage dependent currents in neurones cultured from rat hippocampus

        Author
        Caesar, M.
        Evans, M.L.
        Benham, C.D.
        Attention
        2299/3503
        Abstract
        The novel anticonvulsant SB-204269 inhibits epileptiform afterdischarges induced by high K+ in rat hippocampal slices. Its effects on voltage-gated Na+ currents, measured from cultured hippocampal neurones using whole cell patch clamp, were compared to the effects of existing anticonvulsants. SB-204269 produced no significant tonic block of Na+ currents nor any voltage-dependent and frequency-dependent block at doses 50 to 500 fold higher than its anticonvulsant EC50 of 0.2 μM. In contrast, lamotrigine, phenytoin and carbamazepine at 50 μM, blocked Na+ currents in a voltage-dependent manner. SB-204269 also had no effect on action potential discharges evoked by elevating external K+. These data suggest that direct blockade of voltage-gated channels does not contribute to the anticonvulsant properties of SB-204269 and further support the hypothesis that this compound has a novel mechanism of action.
        Publication date
        1999
        Published in
        Neuroscience Letters
        Published version
        https://doi.org/10.1016/S0304-3940(99)00514-5
        Other links
        http://hdl.handle.net/2299/3503
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