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        Cloning, localisation and functional expression of the human ortholgue of the TREK-1 potassium channel

        Author
        Meadows, H.J.
        Benham, C.D.
        Cairns, W.
        Gloger, I.
        Jennings, C.
        Medhurst, A.D.
        Murdock, P.
        Chapman, C.G.
        Attention
        2299/3504
        Abstract
        We have cloned human TREK-1, one of the newly emerging mammalian family of 2-P domain potassium channels. The channel has 411 amino acids with a 41-amino-acid extension at the C-terminus when compared with the cloned mouse TREK-1 channel. Expression of hTREK-1 produced a substantial hyperpolarising shift in resting membrane potential accompanied by the induction of large, outwardly rectifying, non-inactivating currents which were potassium selective. Pharmacologically, hTREK-1-mediated currents were only blocked to a limited extent by classic potassium channel blockers or open channel pore blockers known to potently inhibit other channels. The channel was reversibly potentiated by arachidonic acid. CNS distribution of hTREK-1 is widespread with higher levels being observed in caudate, putamen, amygdala, thalamus and spinal cord. Only low levels of expression were seen in the majority of peripheral regions. Thus, hTREK-1, although functionally and pharmacologically similar to mouse TREK-1, appears to have a more CNS-specific distribution.
        Publication date
        2000
        Published in
        Pflugers Archiv European Journal of Physiology
        Published version
        https://doi.org/10.1007/s004240050997
        Other links
        http://hdl.handle.net/2299/3504
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