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dc.contributor.authorHayes, P.
dc.contributor.authorMeadows, H.J.
dc.contributor.authorGunthorpe, M.J.
dc.contributor.authorHarries, M.
dc.contributor.authorDuckworth, M.
dc.contributor.authorCairns, W.
dc.contributor.authorHarrison, D. C.
dc.contributor.authorEllington, K.
dc.contributor.authorPrinjha, R.
dc.contributor.authorBarton, A.
dc.contributor.authorMedhurst, A.D.
dc.contributor.authorSmith, G.D.
dc.contributor.authorTopp, S.
dc.contributor.authorSanger, G.
dc.contributor.authorJenkins, O.
dc.contributor.authorBenham, C.D.
dc.contributor.authorGloger, I.
dc.contributor.authorClarke, C. E.
dc.contributor.authorMurdock, P.
dc.contributor.authorTerrett, J.
dc.contributor.authorRandall, A. D.
dc.contributor.authorGloger, I. S.
dc.contributor.authorDavis, J. B.
dc.date.accessioned2009-06-08T12:37:05Z
dc.date.available2009-06-08T12:37:05Z
dc.date.issued2000-11-01
dc.identifier.citationHayes , P , Meadows , H J , Gunthorpe , M J , Harries , M , Duckworth , M , Cairns , W , Harrison , D C , Ellington , K , Prinjha , R , Barton , A , Medhurst , A D , Smith , G D , Topp , S , Sanger , G , Jenkins , O , Benham , C D , Gloger , I , Clarke , C E , Murdock , P , Terrett , J , Randall , A D , Gloger , I S & Davis , J B 2000 , ' Cloning and functional expression of a human orthologue of the rat vanilloid receptor-1 ' Pain , vol. 88 , no. 2 , pp. 205-215 . https://doi.org/10.1016/S0304-3959(00)00353-5
dc.identifier.issn0304-3959
dc.identifier.otherPURE: 126531
dc.identifier.otherPURE UUID: 36476356-00a4-4fe5-9d13-a647ef305c5f
dc.identifier.otherdspace: 2299/3514
dc.identifier.otherScopus: 0034333017
dc.identifier.urihttp://hdl.handle.net/2299/3514
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/03043959. Copyright International Association for the Study of Pain.
dc.description.abstractCapsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Here we describe the cloning of a human vanilloid receptor-1 (hVR1) cDNA containing a 2517 bp open reading frame that encodes a protein with 92% homology to the rat vanilloid receptor-1. Oocytes or mammalian cells expressing this cDNA respond to capsaicin, pH and temperature by generating inward membrane currents. Mammalian cells transfected with human VR1 respond to capsaicin with an increase in intracellular calcium. The human VR1 has a chromosomal location of 17p13 and is expressed in human dorsal root ganglia and also at low levels throughout a wide range of CNS and peripheral tissues. Together the sequence homology, similar expression profile and functional properties confirm that the cloned cDNA represents the human orthologue of rat VR1.en
dc.format.extent16
dc.language.isoeng
dc.relation.ispartofPain
dc.subjectCapsaicin
dc.subjectProtons
dc.subjectpH
dc.subjectTemperature
dc.subjectNociception
dc.titleCloning and functional expression of a human orthologue of the rat vanilloid receptor-1en
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2000-06-06
rioxxterms.versionofrecordhttps://doi.org/10.1016/S0304-3959(00)00353-5
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstypeclosedAccess


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