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TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia

dc.contributor.authorFonfria, E.
dc.contributor.authorMattei, C.
dc.contributor.authorHill, K.
dc.contributor.authorBrown, J.T.
dc.contributor.authorRandall, A.D.
dc.contributor.authorBenham, C.D.
dc.contributor.authorSkaper, S.D.
dc.contributor.authorCampbell, C.A.
dc.contributor.authorCrook, B.
dc.contributor.authorMurdoch, P.R.
dc.contributor.authorWilson, J.M.
dc.contributor.authorMurio, F.P.
dc.contributor.authorOwen, D.
dc.contributor.authorTilling, P.L.
dc.contributor.authorMcNulty, S.
dc.date.accessioned2009-06-08T12:53:43Z
dc.date.available2009-06-08T12:53:43Z
dc.date.issued2006
dc.identifier.citationFonfria , E , Mattei , C , Hill , K , Brown , J T , Randall , A D , Benham , C D , Skaper , S D , Campbell , C A , Crook , B , Murdoch , P R , Wilson , J M , Murio , F P , Owen , D , Tilling , P L & McNulty , S 2006 , ' TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microglia ' , Journal of Receptors and Signal Transduction Research , vol. 26 , no. 3 , pp. 179-198 . https://doi.org/10.1080/10799890600637522
dc.identifier.issn1079-9893
dc.identifier.otherdspace: 2299/3515
dc.identifier.urihttp://hdl.handle.net/2299/3515
dc.descriptionOriginal article can be found at: http://www.informaworld.com/smpp/title~content=t713597278 Copyright Informa / Taylor and Francis Group. DOI: 10.1080/10799890600637522 [Full text of this article is not available in the UHRA]
dc.description.abstractWe report the detailed expression profile of TRPM2 mRNA within the human central nervous system (CNS) and demonstrate increased TRPM2 mRNA expression at 1 and 4 weeks following ischemic injury in the rat transient middle cerebral artery occlusion (tMCAO) stroke model. Microglial cells play a key role in pathology produced following ischemic injury in the CNS and possess TRPM2, which may contribute to stroke-related pathological responses. We show that TRPM2 mRNA is present in the human C13 microglial cell line and is reduced by antisense treatment. Activation of C13 cells by interleukin-1β leads to a fivefold increase of TRPM2 mRNA demonstrating transcriptional regulationen
dc.language.isoeng
dc.relation.ispartofJournal of Receptors and Signal Transduction Research
dc.titleTRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated and functionally expressed in C13 microgliaen
dc.contributor.institutionDepartment of Human and Environmental Sciences
dc.contributor.institutionTRP Ion channels
dc.contributor.institutionDepartment of Clinical, Pharmaceutical and Biological Science
dc.contributor.institutionBasic and Clinical Science Unit
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionCentre for Research in Mechanisms of Disease and Drug Discovery
dc.description.statusPeer reviewed
rioxxterms.versionofrecord10.1080/10799890600637522
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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