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        Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments

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        902132.pdf (PDF, 187Kb)
        Author
        Traynor, M.J.
        Brown, Marc
        Pannala, A.
        Beck, P.
        Martin, G. P.
        Attention
        2299/3636
        Abstract
        Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol.
        Publication date
        2008
        Published in
        Drug Development and Industrial Pharmacy
        Published version
        https://doi.org/10.1080/03639040801929240
        Other links
        http://hdl.handle.net/2299/3636
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