dc.contributor.author | Traynor, M.J. | |
dc.contributor.author | Brown, Marc | |
dc.contributor.author | Pannala, A. | |
dc.contributor.author | Beck, P. | |
dc.contributor.author | Martin, G. P. | |
dc.date.accessioned | 2009-06-30T08:18:12Z | |
dc.date.available | 2009-06-30T08:18:12Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Traynor , M J , Brown , M , Pannala , A , Beck , P & Martin , G P 2008 , ' Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments ' , Drug Development and Industrial Pharmacy , vol. 34 , no. 8 , pp. 885-889 . https://doi.org/10.1080/03639040801929240 | |
dc.identifier.issn | 0363-9045 | |
dc.identifier.other | dspace: 2299/3636 | |
dc.identifier.other | ORCID: /0000-0001-7332-0011/work/32634808 | |
dc.identifier.uri | http://hdl.handle.net/2299/3636 | |
dc.description | Original article can be found at: http://www.informaworld.com/smpp/1903179435-18973042/title~content=t713597245 Copyright Informa Healthcare | |
dc.description.abstract | Recent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol. | en |
dc.format.extent | 5 | |
dc.format.extent | 191582 | |
dc.language.iso | eng | |
dc.relation.ispartof | Drug Development and Industrial Pharmacy | |
dc.subject | tramadol | |
dc.subject | controlled release | |
dc.subject | alcohol | |
dc.subject | in vitro | |
dc.subject | POSTOPERATIVE PAIN | |
dc.subject | MATRICES | |
dc.title | Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments | en |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy | |
dc.contributor.institution | Centre for Research into Topical Drug Delivery and Toxicology | |
dc.contributor.institution | Toxicology | |
dc.contributor.institution | Pharmaceutics | |
dc.contributor.institution | Nanopharmaceutics | |
dc.contributor.institution | Pharmaceutical Analysis and Product Characterisation | |
dc.contributor.institution | Skin and Nail Group | |
dc.description.status | Peer reviewed | |
dc.identifier.url | http://www.scopus.com/inward/record.url?scp=49449100469&partnerID=8YFLogxK | |
rioxxterms.versionofrecord | 10.1080/03639040801929240 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |