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dc.contributor.authorTraynor, M.J.
dc.contributor.authorBrown, Marc
dc.contributor.authorPannala, A.
dc.contributor.authorBeck, P.
dc.contributor.authorMartin, G. P.
dc.date.accessioned2009-06-30T08:18:12Z
dc.date.available2009-06-30T08:18:12Z
dc.date.issued2008
dc.identifier.citationTraynor , M J , Brown , M , Pannala , A , Beck , P & Martin , G P 2008 , ' Influence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experiments ' , Drug Development and Industrial Pharmacy , vol. 34 , no. 8 , pp. 885-889 . https://doi.org/10.1080/03639040801929240
dc.identifier.issn0363-9045
dc.identifier.otherPURE: 185092
dc.identifier.otherPURE UUID: fb287971-9a85-4a21-81c2-dc5dcfbc0cef
dc.identifier.otherdspace: 2299/3636
dc.identifier.otherWOS: 000258245200013
dc.identifier.otherScopus: 49449100469
dc.identifier.otherORCID: /0000-0001-7332-0011/work/32634808
dc.identifier.urihttp://hdl.handle.net/2299/3636
dc.descriptionOriginal article can be found at: http://www.informaworld.com/smpp/1903179435-18973042/title~content=t713597245 Copyright Informa Healthcare
dc.description.abstractRecent warnings by regulatory bodies and a product recall by the FDA have generated much interest in the area of dose dumping from controlled-release opioid analgesic formulations when coingested with alcohol. It was the aim of this study to address this issue and in doing so, gain understanding on how alcohol-induced effects may be avoided. In this study, tramadol release from Ultram (R) ER tablets and T-long (R) capsules was significantly increased in the presence of ethanol. Conversely, a decrease in the rate of tramadol release was seen from Tridural (TM) extended-release tablets in the presence of alcohol.en
dc.format.extent5
dc.language.isoeng
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.subjecttramadol
dc.subjectcontrolled release
dc.subjectalcohol
dc.subjectin vitro
dc.subjectPOSTOPERATIVE PAIN
dc.subjectMATRICES
dc.titleInfluence of alcohol on the release of tramadol from 24-h controlled-release formulations during in vitro dissolution experimentsen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.contributor.institutionCentre for Research into Topical Drug Delivery and Toxicology
dc.contributor.institutionToxicology
dc.contributor.institutionPharmaceutics
dc.contributor.institutionNanopharmaceutics
dc.contributor.institutionPharmaceutical Analysis and Product Characterisation
dc.contributor.institutionSkin and Nail Group
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=49449100469&partnerID=8YFLogxK
rioxxterms.versionofrecordhttps://doi.org/10.1080/03639040801929240
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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