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dc.contributor.authorModdaresi, Mojgan
dc.contributor.authorTamburic, Slobodanka
dc.contributor.authorWilliams, Stefanie
dc.contributor.authorJones, Stuart A.
dc.contributor.authorZhao, Yanjun
dc.contributor.authorBrown, Marc
dc.identifier.citationModdaresi , M , Tamburic , S , Williams , S , Jones , S A , Zhao , Y & Brown , M 2009 , ' Effects of lipid nanocarriers on the performance of topical vehicles in vivo ' , Journal of Cosmetic Dermatology , vol. 8 , no. 2 , pp. 136-143 .
dc.identifier.otherPURE: 185064
dc.identifier.otherPURE UUID: f1aa3d9f-f098-410a-9da0-3c148bfa17e3
dc.identifier.otherdspace: 2299/3657
dc.identifier.otherWOS: 000208136800011
dc.identifier.otherScopus: 66949137826
dc.description‘The definitive version is available at '. Copyright Wiley Periodicals. DOI: 10.1111/j.1473-2165.2009.00440.x [Full text of this article is not available in the UHRA]
dc.description.abstractBackground/aims Nanocarrier systems have been extensively studied for their suitability in personal care formulations. Theoretically, they could enhance skin delivery of active compounds, thereby improving in vivo efficacy of the products. As such the aim of this study was to evaluate the effect of a lipid nanocarrier (LNC) system loaded with tocopheryl acetate (TA) on the hydration, biomechanical properties, and antioxidant capacity of human skin, when used in two different vehicles, and compare it with a non-LNC formulation. Methods TA-loaded lipid nanocarriers (TA-LNCs) were produced by the phase inversion method, using physiological lipids and purified by ultra-centrifugation. They were incorporated into a hydrophilic gel and foam, and their performance compared with a saturated TA solution in silicon oil. Skin hydration and biomechanical properties were measured by means of a corneometer and a cutometer, respectively, while a high-resolution spectrophotometer was used to assess skin redness after stimulation by methyl nicotinate in a micro-inflammatory test. Both short-term (3 h) and long-term trials (4 weeks) were performed. Results The results confirmed that the LNCs enhanced skin hydration in both studies, while skin viscoelastic parameters remained practically unchanged during the 4-week study. The antioxidant assessment failed to show significant difference between the test sites. Conclusions TA-loaded LNCs exhibited the ability to enhance skin hydration, while their effect on skin biomechanical properties and on antioxidant efficacy could not be statistically proved.en
dc.relation.ispartofJournal of Cosmetic Dermatology
dc.subjectlipid nanocarriers
dc.subjectvitamin E
dc.subjectskin hydration
dc.subjectskin viscoelasticity
dc.subjectantioxidant efficacy
dc.titleEffects of lipid nanocarriers on the performance of topical vehicles in vivoen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
rioxxterms.typeJournal Article/Review

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