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dc.contributor.authorBayley, P.M.
dc.contributor.authorSchilstra, M.
dc.contributor.authorMartin, S.R.
dc.date.accessioned2009-09-30T08:08:59Z
dc.date.available2009-09-30T08:08:59Z
dc.date.issued1989
dc.identifier.citationBayley , P M , Schilstra , M & Martin , S R 1989 , ' A Lateral Cap model of microtubule dynamic instability ' FEBS Letters , vol. 259 , no. 1 , pp. 181-184 . https://doi.org/10.1016/0014-5793(89)81523-6
dc.identifier.issn0014-5793
dc.identifier.otherPURE: 99045
dc.identifier.otherPURE UUID: 2c55df28-5e93-48c2-9f99-4fbf7eb48311
dc.identifier.otherdspace: 2299/3903
dc.identifier.otherScopus: 0024785590
dc.identifier.urihttp://hdl.handle.net/2299/3903
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/00145793 Copyright Federation of European Biochemical Societies. [Full text of this article is not available in the UHRA]
dc.description.abstractThe co-existence and interconversion of growing and shrinking microtubules have been termed ‘dynamic instability’, and have been directly observed to occur under a variety of conditions in vitro and in vivo. Previous modelling was based on the concept of an extensive, fluctuating cap of tubulin-GTP to stabilise growing microtubules. A quantitative kinetic model is now presented in which only the terminal layer of the multi-start helical microtubule lattice contains tubulin-GTP molecules, comprising a ‘Lateral Cap’. In Monte Carlo numerical simulation, this model readily reproduces the decisive experimental evidence of microtubule dynamics, and predicts a co-operative mechanism for microtubule transitions. The model also suggests how differing kinetic properties at opposite ends are the result of the intrinsic polarity of the microtubule lattice, reflecting the polarity of the tubutin α/β heterodimer.en
dc.language.isoeng
dc.relation.ispartofFEBS Letters
dc.titleA Lateral Cap model of microtubule dynamic instabilityen
dc.contributor.institutionSchool of Computer Science
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Computer Science
rioxxterms.versionofrecordhttps://doi.org/10.1016/0014-5793(89)81523-6
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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