dc.contributor.author | Martin, S.R. | |
dc.contributor.author | Schilstra, M. | |
dc.contributor.author | Bayley, P.M. | |
dc.date.accessioned | 2009-09-30T08:44:51Z | |
dc.date.available | 2009-09-30T08:44:51Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | Martin , S R , Schilstra , M & Bayley , P M 1991 , ' Opposite-end behaviour of dynamic microtubules ' , BBA - General Subjects , vol. 1073 , no. 3 , pp. 555-561 . https://doi.org/10.1016/0304-4165(91)90230-E | |
dc.identifier.issn | 0304-4165 | |
dc.identifier.other | PURE: 85671 | |
dc.identifier.other | PURE UUID: af69ab3a-85f4-4314-9eba-7f179259c662 | |
dc.identifier.other | dspace: 2299/3906 | |
dc.identifier.other | Scopus: 0025825156 | |
dc.identifier.uri | http://hdl.handle.net/2299/3906 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/03044165 Copyright Elsevier B.V. [Full text of this article is not available in the UHRA] | |
dc.description.abstract | Microtubules are dynamic polar structures with different kinetic properties at the two ends. The inherent asymmetry of the microtubule lattice determines that the relationship between the addition reaction of tubulin-GTP and the associated hydrolysis of a tubulin-GTP on the polymer is different at the two ends of the microtubule. We present a unified treatment for both ends of the microtubule, using the principles of the Lateral Cap formulation for microtubule dynamic instability. This shows that the two ends can exhibit significantly different dynamic properties in terms of amplitudes and lifetimes of growth and shrinking, depending on the relative importance of longitudinal and lateral contacts in the coupling of tubulin-GTP hydrolysis. These predictions are readily amenable to experimental verification. This modelling suggests that fine details of the subunit-subunit interactions at the microtubule end can determine the characteristic differences in kinetic behaviour of the opposite ends of dynamic microtubules. Variation of these interactions would provide a potentially sensitive general mechanism for the control of such dynamics, both in vitro and in vivo. | en |
dc.language.iso | eng | |
dc.relation.ispartof | BBA - General Subjects | |
dc.title | Opposite-end behaviour of dynamic microtubules | en |
dc.contributor.institution | School of Computer Science | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | https://doi.org/10.1016/0304-4165(91)90230-E | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |