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dc.contributor.authorFiala, Sarah
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart A.
dc.date.accessioned2010-01-18T11:17:43Z
dc.date.available2010-01-18T11:17:43Z
dc.date.issued2008-12
dc.identifier.citationFiala , S , Brown , M & Jones , S A 2008 , ' An investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranes ' , Journal of Pharmacy and Pharmacology , vol. 60 , no. 12 , pp. 1615-1623 . https://doi.org/10.1211/jpp/60.12.0007
dc.identifier.issn0022-3573
dc.identifier.otherPURE: 185175
dc.identifier.otherPURE UUID: 29b95381-cfc5-41dc-b4e3-88330147338c
dc.identifier.otherdspace: 2299/4144
dc.identifier.otherWOS: 000261475100007
dc.identifier.otherScopus: 56849115445
dc.identifier.urihttp://hdl.handle.net/2299/4144
dc.descriptionOriginal article can be found at: http://www.medicinescomplete.com/journals/jpp/current/ Copyright Pharmaceutical Press. DOI: 10.1211/jpp/60.12.0007 [Full text of this article is not available in the UHRA]
dc.description.abstractFew studies have assessed the impact of binary systems on the fundamental mathematical models that describe drug permeation. The aim of this work was to determine the influence of varying the proportions of prilocaine and lidocaine in a binary saturated solution on mass transfer across synthetic membranes. Infinite-dose permeation studies were performed using Franz diffusion cells with either regenerated cellulose or silicone membranes, and partition coefficients were determined by drug loss over 24 h. There was a linear relationship between the flux of prilocaine and lidocaine through regenerated cellulose membrane (R2 ≥ 0.985, n = 5) and their normalised ratio in solution. This linear model was also applicable for the permeation of prilocaine through silicone membrane (R2 = 0.991, n = 5), as its partition coefficient was independent of the drug ratio (15.84 ± 1.41). However, the partition coefficient of lidocaine increased from 27.22 ± 1.68 to 47.03 ± 3.32 as the ratio of prilocaine increased and this resulted in a non-linear relationship between permeation and drug ratio. Irrespective of the membrane used, the permeation of one drug from a binary system was hindered by the presence of the second, which could be attributed to a reduction in available membrane diffusion volume.en
dc.format.extent9
dc.language.isoeng
dc.relation.ispartofJournal of Pharmacy and Pharmacology
dc.subjectH-BONDING GROUPS
dc.subjectIN-VITRO
dc.subjectSUPERSATURATED SOLUTIONS
dc.subjectCELLOPHANE MEMBRANES
dc.subjectARTIFICIAL MEMBRANES
dc.subjectENHANCED PERMEATION
dc.subjectDERMAL DELIVERY
dc.subjectHUMAN SKIN
dc.subjectRELEASE
dc.subjectPERMEABILITY
dc.titleAn investigation into the influence of binary drug solutions upon diffusion and partition processes in model membranesen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
dcterms.dateAccepted2008-12
rioxxterms.versionofrecordhttps://doi.org/10.1211/jpp/60.12.0007
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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