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dc.contributor.authorZhao, Yanjun
dc.contributor.authorModdaresi, Mojgan
dc.contributor.authorJones, Stuart A.
dc.contributor.authorBrown, Marc
dc.date.accessioned2010-01-18T11:42:04Z
dc.date.available2010-01-18T11:42:04Z
dc.date.issued2009-08
dc.identifier.citationZhao , Y , Moddaresi , M , Jones , S A & Brown , M 2009 , ' A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ ' European Journal of Pharmaceutics and Biopharmaceutics , vol. 72 , no. 3 , pp. 521-528 . https://doi.org/10.1016/j.ejpb.2009.03.002
dc.identifier.issn0939-6411
dc.identifier.otherPURE: 185159
dc.identifier.otherPURE UUID: 8e698165-0f7c-4e95-9d11-b8cb4e1db2e2
dc.identifier.otherdspace: 2299/4146
dc.identifier.otherWOS: 000268119300006
dc.identifier.otherScopus: 67449155891
dc.identifier.urihttp://hdl.handle.net/2299/4146
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/09396411 Copyright Elsevier B.V. DOI: 10.1016/j.ejpb.2009.03.002
dc.description.abstractTopical nanoparticles are usually applied using semi-solid formulations, but the delivery process is often inefficient due to the poor drug release from the particles. The aim of this study was to investigate the capability of a dynamic foam to break open nanoparticles upon application to the skin and enhance drug delivery efficiency. Vitamin E acetate (VEAc) was selected as a model drug and loaded into lipid nanoparticles (50-60 nm) prepared by phase inversion. The highest drug loading was 18.9 +/- 1.2 mg/ml and the corresponding encapsulation efficiency was 81.5 +/- 4.1 %. Dynamic foams were generated by emulsifying VEAc-loaded nanoparticle Suspensions with hydrofluoroalkane using pluronic L62D. Ail in vitro permeation study demonstrated that VEAc did not release from the nanoparticles when administered as ail aqueous Suspension, but attained a flux of 18.0 +/- 2.1 (mu g cm(-2) h(-1)) when applied using the foam. Drug release from the foam was shown to be a consequence of nanoparticle modification after dose administration and this led to the foam delivering 0.7 +/- 0.3% VEAc into the stratum corneum (SC) when applied to human skin. (C) 2009 Elsevier B.V. All rights reserved.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutics and Biopharmaceutics
dc.subjectFoam
dc.subjectVehicle
dc.subjectVitamin E acetate
dc.subjectNanoparticle
dc.subjectPenetration
dc.subjectSOLID LIPID NANOPARTICLES
dc.subjectOXIDE) TRIBLOCK COPOLYMERS
dc.subjectPERCUTANEOUS-ABSORPTION
dc.subjectDELIVERY SYSTEMS
dc.subjectVITAMIN-E
dc.subjectSKIN
dc.subjectENHANCEMENT
dc.subjectPENETRATION
dc.subjectFORMULATION
dc.subjectPERMEATION
dc.titleA dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejpb.2009.03.002
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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