dc.contributor.author | Zhao, Yanjun | |
dc.contributor.author | Moddaresi, Mojgan | |
dc.contributor.author | Jones, Stuart A. | |
dc.contributor.author | Brown, Marc | |
dc.date.accessioned | 2010-01-18T11:42:04Z | |
dc.date.available | 2010-01-18T11:42:04Z | |
dc.date.issued | 2009-08 | |
dc.identifier.citation | Zhao , Y , Moddaresi , M , Jones , S A & Brown , M 2009 , ' A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 72 , no. 3 , pp. 521-528 . https://doi.org/10.1016/j.ejpb.2009.03.002 | |
dc.identifier.issn | 0939-6411 | |
dc.identifier.other | dspace: 2299/4146 | |
dc.identifier.uri | http://hdl.handle.net/2299/4146 | |
dc.description | Original article can be found at: http://www.sciencedirect.com/science/journal/09396411 Copyright Elsevier B.V. DOI: 10.1016/j.ejpb.2009.03.002 | |
dc.description.abstract | Topical nanoparticles are usually applied using semi-solid formulations, but the delivery process is often inefficient due to the poor drug release from the particles. The aim of this study was to investigate the capability of a dynamic foam to break open nanoparticles upon application to the skin and enhance drug delivery efficiency. Vitamin E acetate (VEAc) was selected as a model drug and loaded into lipid nanoparticles (50-60 nm) prepared by phase inversion. The highest drug loading was 18.9 +/- 1.2 mg/ml and the corresponding encapsulation efficiency was 81.5 +/- 4.1 %. Dynamic foams were generated by emulsifying VEAc-loaded nanoparticle Suspensions with hydrofluoroalkane using pluronic L62D. Ail in vitro permeation study demonstrated that VEAc did not release from the nanoparticles when administered as ail aqueous Suspension, but attained a flux of 18.0 +/- 2.1 (mu g cm(-2) h(-1)) when applied using the foam. Drug release from the foam was shown to be a consequence of nanoparticle modification after dose administration and this led to the foam delivering 0.7 +/- 0.3% VEAc into the stratum corneum (SC) when applied to human skin. (C) 2009 Elsevier B.V. All rights reserved. | en |
dc.format.extent | 8 | |
dc.language.iso | eng | |
dc.relation.ispartof | European Journal of Pharmaceutics and Biopharmaceutics | |
dc.subject | Foam | |
dc.subject | Vehicle | |
dc.subject | Vitamin E acetate | |
dc.subject | Nanoparticle | |
dc.subject | Penetration | |
dc.subject | SOLID LIPID NANOPARTICLES | |
dc.subject | OXIDE) TRIBLOCK COPOLYMERS | |
dc.subject | PERCUTANEOUS-ABSORPTION | |
dc.subject | DELIVERY SYSTEMS | |
dc.subject | VITAMIN-E | |
dc.subject | SKIN | |
dc.subject | ENHANCEMENT | |
dc.subject | PENETRATION | |
dc.subject | FORMULATION | |
dc.subject | PERMEATION | |
dc.title | A dynamic topical hydrofluoroalkane foam to induce nanoparticle modification and drug release in situ | en |
dc.contributor.institution | Health & Human Sciences Research Institute | |
dc.contributor.institution | School of Life and Medical Sciences | |
dc.contributor.institution | Department of Pharmacy | |
dc.description.status | Peer reviewed | |
rioxxterms.versionofrecord | 10.1016/j.ejpb.2009.03.002 | |
rioxxterms.type | Journal Article/Review | |
herts.preservation.rarelyaccessed | true | |