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dc.contributor.authorZhao, Yanjun
dc.contributor.authorBrown, Marc
dc.contributor.authorJones, Stuart A.
dc.date.accessioned2010-01-18T11:47:36Z
dc.date.available2010-01-18T11:47:36Z
dc.date.issued2009-06-28
dc.identifier.citationZhao , Y , Brown , M & Jones , S A 2009 , ' Engineering novel topical foams using hydrofluroalkane emulsions stabilised with pluronic surfactants ' European Journal of Pharmaceutical Sciences , vol. 37 , no. 3-4 , pp. 370-377 . https://doi.org/10.1016/j.ejps.2009.03.007
dc.identifier.issn0928-0987
dc.identifier.otherPURE: 185190
dc.identifier.otherPURE UUID: bc7c66bb-7fda-42fb-9870-7f5d3b0d0e41
dc.identifier.otherdspace: 2299/4147
dc.identifier.otherWOS: 000267479500024
dc.identifier.otherScopus: 67349130576
dc.identifier.urihttp://hdl.handle.net/2299/4147
dc.descriptionOriginal article can be found at: http://www.sciencedirect.com/science/journal/09280987 Copyright Elsevier B.V. DOI: 10.1016/j.ejps.2009.03.007 [Full text of this article is not available in the UHRA]
dc.description.abstractAesthetics are very important for topical products and as a consequence elegant vehicles such as sprays and foams are often preferred by patients. Pressurised systems are ideal to dose foams, however, as so little is known about the influence of formulation characteristics on foam properties, the rational design of these systems difficult. This study aimed to assess the capability of pluronic surfactants to stabilise topical pressurised hydrofluoroalkane (HFA) emulsions and attempted to define the formulation characteristics that had an impact upon foam properties. In situ phase diagrams and conductivity measurements were used to characterise the HFA emulsions. Cryo-scanning electron microscopy images, collapse time (C-t) and wetting time (W-t) were used to assess the foams post dosing, i.e. after removal of the HFA. The results indicated that foam stability was a direct function of HFA emulsion type; HFA-in-water (HIW) emulsions generated stable foams,they had 30-100 mu m bubble diameter with c.a. 40 bubbles in a 0.45 mm x 0.40 mm area; water-in-HFA (WIH) emulsions created quick-breaking foams they contained 20-200 mu m sized bubbles and had 20 bubbles in an area of 0.45 mm x 0.40 mm. Therefore, the rational design of pressurised topical foams can be achieved if the formulation is analysed in situ. (C) 2009 Elsevier B.V. All rights reserved.en
dc.format.extent8
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.subjectFoam
dc.subjectHydrofluoroalkane
dc.subjectPluronic
dc.subjectEmulsion
dc.subjectTopical
dc.subjectMETERED-DOSE INHALERS
dc.subjectCLOBETASOL PROPIONATE FOAM
dc.subjectHYDROFLUOROALKANE PROPELLANTS
dc.subjectTRIBLOCK COPOLYMERS
dc.subjectWATER INTERFACE
dc.subjectSPRAY
dc.subjectFORMULATION
dc.subjectVEHICLES
dc.subjectSKIN
dc.subjectSOLUBILIZATION
dc.titleEngineering novel topical foams using hydrofluroalkane emulsions stabilised with pluronic surfactantsen
dc.contributor.institutionHealth & Human Sciences Research Institute
dc.contributor.institutionSchool of Life and Medical Sciences
dc.contributor.institutionDepartment of Pharmacy
dc.description.statusPeer reviewed
dc.relation.schoolSchool of Life and Medical Sciences
rioxxterms.versionofrecordhttps://doi.org/10.1016/j.ejps.2009.03.007
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue
herts.rights.accesstyperestrictedAccess


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