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dc.contributor.authorFineberg, Naomi
dc.contributor.authorSivakumaran, T.
dc.contributor.authorRoberts, A.
dc.contributor.authorGale, T.M.
dc.date.accessioned2010-02-09T15:34:48Z
dc.date.available2010-02-09T15:34:48Z
dc.date.issued2005
dc.identifier.citationFineberg , N , Sivakumaran , T , Roberts , A & Gale , T M 2005 , ' Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study ' , International Clinical Psychopharmacology , vol. 20 , no. 4 , pp. 223-226 . < http://www.intclinpsychopharm.com/ >
dc.identifier.issn0268-1315
dc.identifier.otherPURE: 193323
dc.identifier.otherPURE UUID: 8a7ad389-c8eb-4957-8ebc-8e76bb2e2a7c
dc.identifier.otherdspace: 2299/4240
dc.identifier.otherScopus: 21244482555
dc.identifier.urihttp://hdl.handle.net/2299/4240
dc.descriptionOriginal article can be found at: http://www.intclinpsychopharm.com/ Copyright Lippincott Williams & Wilkins, Inc. [Full text of this article is not available in the UHRA]
dc.description.abstractThis study aimed to determine the efficacy and tolerability of adding quetiapine to a serotonin reuptake inhibitor in treatment-resistant obsessive-compulsive disorder (OCD). Twenty-one adult treatment-resistant OCD patients were randomized to 16 weeks of augmentation with either quetiapine (n=11) or placebo (n=10). Patients with significant comorbidities, including tic-spectrum disorders, were not included. The treatment was well tolerated, with only one premature dropout in each treatment-group. The primary analysis showed that individuals in the quetiapine-treated group showed a 14% mean improvement in baseline Yale-Brown Obsessive-Compulsive Scale scores at study endpoint compared with a 6% improvement in those treated with placebo, but this difference did not reach statistical significance (F<1). Three patients treated with quetiapine met criteria for clinical response, compared to one patient who was treated with placebo. Larger studies are needed to explore the efficacy of second generation antipsychotics, such as quetiapine, when used as adjunct treatment in resistant OCD.en
dc.language.isoeng
dc.relation.ispartofInternational Clinical Psychopharmacology
dc.titleAdding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment studyen
dc.contributor.institutionDepartment of Psychology
dc.contributor.institutionCentre for Health Services and Clinical Research
dc.contributor.institutionDepartment of Psychology and Sports Sciences
dc.contributor.institutionSchool of Life and Medical Sciences
dc.description.statusPeer reviewed
dc.identifier.urlhttp://www.intclinpsychopharm.com/
rioxxterms.typeJournal Article/Review
herts.preservation.rarelyaccessedtrue


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